首页|HSP70基因多态性与职业性噪声性听力损失易感性关联分析

HSP70基因多态性与职业性噪声性听力损失易感性关联分析

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目的 探讨热休克蛋白70(HSP70)基因多态性与职业性噪声性听力损失(ONIHL)易感性的关系.方法 采用病例-对照研究方法,选择229名ONIHL工人为病例组,以年龄、噪声作业工龄、噪声接触水平等与病例组相近的229名听力正常工人为对照组.对2组人群进行职业健康检查,采集周围静脉血提取DNA,采用MassArray系统对HSP70基因3个单核苷酸多态性位点进行基因分型检测.结果 HSP70基因rs2227956、rs1043618和rs1061581位点在对照组人群等位基因频率分布均符合遗传学Hardy-Weinberg平衡定律(P值均＞0.05).2组人群rs2227956位点不同基因型分布和等位基因频率分布比较,差异均有统计学意义(P值均＜0.05);2组人群rs1043618、rs1061581位点不同基因型分布和等位基因频率分布分别比较,差异均无统计学意义(P值均＞0.05).在排除年龄、噪声作业工龄、个体噪声接触强度、吸烟和饮酒的影响后,携带rs2227956位点AG和AG+GG基因型个体罹患ONIHL的风险均高于携带AA基因型者(P值均＜0.05);携带rs2227956位点G等位基因个体罹患ONIHL的风险高于携带A等位基因者(P＜0.05).未发现rs1043618和rs1061581位点多态性与罹患ONIHL风险有关联(P值均＞0.05).结论 HSP70基因rs2227956位点多态性与噪声作业人群ONIHL易感性相关,G等位基因可能是噪声作业人群罹患ONIHL的危险因素.
Study on the relationship between HSP70 polymorphism and susceptibility to occupational noise-induced hearing loss
Objective To investigate the correlation between genetic polymorphism of heat shock proteins 70(HSP70)and susceptibility to occupational noise-induced hearing loss(ONIHL).Methods A total of 229 ONIHL workers were selected as the case group and 229 healthy workers with similar age,years of noise exposure,and noise exposure levels were selected as the control group using the case-control study method.Occupational health examinations were conducted on both groups,and peripheral blood of individuals was collected for DNA extraction.The genotypes of three single nucleotide polymorphisms of the HSP70 were detected using the MassArray system.Results The allele frequency distribution of HSP70 rs2227956,rs1043618,and rs1061581 in the control group was in Hardy-Weinberg equilibrium(all P＞0.05).The genotype and allele frequency distribution of rs2227956 was significantly different between the two groups(all P＜0.05),while no significant difference was found for rs1043618 and rs1061581(all P＞0.05).After adjusting for age,years of noise exposure,individual noise exposure level,smoking,and drinking,individuals with AG and AG+GG genotypes of rs2227956 had a higher risk of ONIHL than those with AA genotype(all P＜0.05).The risk of ONIHL was higher in individuals with G allele of rs2227956 than in those with A allele(P＜0.05).No correlation was found between rs1043618 and rs1061581 polymorphisms and the risk of ONIHL(all P＞0.05).Conclusion The rs2227956 polymorphism of the HSP70 gene is correlated with susceptibility to ONIHL in noise-exposed workers,and the G allele is a risk factor for ONIHL in this population.

NoiseHearing lossGenetic polymorphismHeat shock protein 70SusceptibilityRelationship analysis

谢春姣、李燕茹、黄丽丽、李艳华、刘影玫、傅惠芬、王致

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广州市职业病防治院,广东广州 510620

噪声 听力损失 基因多态性 热休克蛋白70 易感性 关联分析

广州市卫生健康科技项目广州市卫生健康科技项目广州市科学技术局重点研发计划项目广州市医学重点学科建设项目(2021-2023年)广州市市校(院)企联合资助专题(广州市职业环境与健康重点实验室)

20231A01106220231A0110592022060100612023A03J0502

2024

10.20001/j.issn.2095-2619.20240204

中国职业医学
中华预防医学会 华南区域劳动卫生职业病防治中心

中国职业医学

CSTPCD
影响因子：1.011
ISSN：2095-2619
年,卷(期)：2024.51(1)
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