Discussion on the Mechanism of Qingmai Drink in Treating Lower Extremity Arteriosclerosis Occlusive Disease Based on Network Pharmacology
Objective To discuss the mechanism of Qingmai drink in treating lower extremity arteriosclerosis occlusive disease based on network pharmacology.Methods By searching and screening the active ingredients of Qingmai drink and the genes related to lower limb arteriosclerosis through multiple databases,the"drug-active ingredient-target-disease"network was constructed,and gene on-tology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis and molecular linkage were carried out.Re-sults A total of 62 active ingredients of Qingmai drink were screened,mainly related to cell signaling(cell proliferation,cell migration,cell apoptosis,etc.),inflammatory response,angiogenesis,etc.It mainly acts on tumor necrosis factor(TNF),serine/threonine kinase 1(AKT1),glyceraldehyde-3-phosphate dehydrogenase(GAPDH)and other targets,and participates in phosphatidylinositol 3 kinase(PI3K-serine/threonine kinase(AKT),mitogen-activated protein kinase(MAPK)and other signaling pathways.Conclusion The study explained the mechanism of Qingmai drink in treating ASO at the level of network pharmacology.
万方数据
维普
