首页|基于脑-肠-菌轴探讨调补肝脾法治疗功能性消化不良的作用机制

基于脑-肠-菌轴探讨调补肝脾法治疗功能性消化不良的作用机制

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功能性消化不良(FD)作为临床常见疾病,其发病机制在现代医学方面被证实与胃肠动力、内脏敏感性、胃肠微生态等直接相关.脑-肠-菌轴作为一条人体的特殊通路,可较好地阐释其复杂的病理机制.中医药在FD的治疗方面有着十分确切的效果.从中医理论角度,脾胃之"运""化"与现代医学胃肠动力、营养代谢等具有高度相似之处;而肝主疏泄影响脾胃气机,调畅情志影响思维等功能将中枢系统与胃肠道联系在一起,与现代医学"脑-肠-菌轴"高度相似.文章从中西医两方面论治FD,加强了对其病因病机与治则治法的认识,并拓展了中医调补肝脾法的思路.
The Mechanism of Action of Tonifying Liver and Spleen Method in the Treatment of Functional Dyspepsia Based on Brain-intestine-bacteria Axis
Functional dyspepsia,as a common clinical disease,its pathogenesis has been proved to be directly related to gastrointestinal dynamics,visceral sensitivity,gastrointestinal microecology,etc.in modern medicine.The brain-intestinal-bacterial axis,as a special pathway in the human body,can better explain its complex pathological mechanism.Traditional Chinese medicine has very precise effi-cacy in the treatment of functional dyspepsia.From the perspective of Chinese medicine theory,the"transportation"and"transforma-tion"of the spleen and stomach are highly similar to the gastrointestinal dynamics and nutritional metabolism of modern medicine,and the liver's main function is to influence the qi of the spleen and stomach and to smooth the flow of qi.The functions of the liver,which is re-sponsible for the drainage,influencing the qi of the spleen and stomach,and the emotion influencing the thinking,etc.link the central sys-tem with the gastrointestinal tract,which is highly similar to the"brain-intestinal-bacteria axis"of modern medicine.The mutual treat-ment of functional dyspepsia from both traditional Chinese medicine and Western medicine can strengthen the understanding of its etiol-ogy,pathogenesis,and treatment principles and methods,and expand the application of Chinese medicine to tonify the liver and spleen.

epigastric painfunctional dyspepsiabrain-intestine-bacterial axismechanism of actiontherapy of integrated tradi-tional Chinese and Western medicine

周擎天、邵岩峰、于莉、林平

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福建中医药大学附属第三人民医院脾胃病科,福建 福州 350003

福建中医药大学林平中医药传承工作室,福建 福州 350003

胃脘痛 功能性消化不良 脑-肠-菌轴 作用机制 中西医结合疗法

2025

中国中医药现代远程教育
世中联(北京)远程教育科技发展中心

中国中医药现代远程教育

影响因子:0.531
ISSN:1672-2779
年,卷(期):2025.23(1)