Study on the Mechanism of Action of Jianpi Xifeng Decoction in the Treatment of Diarrhea-predominant Irritable Bowel Syndrome Based on Network Pharmacology and Molecular Docking
Study on the Mechanism of Action of Jianpi Xifeng Decoction in the Treatment of Diarrhea-predominant Irritable Bowel Syndrome Based on Network Pharmacology and Molecular Docking
Objective To investigate the mechanism of action of Jianpi Xifeng decoction in the treatment of diarrhea-predominant irri-table bowel syndrome(IBS-D)by means of network pharmacology and molecular docking methods.Methods The active ingredients and predictions of Jianpi Xifeng decoction were performed on TCMSP,and three databases were utilized to search for the relevant tar-gets of IBS-D.The common targets were then selected for compound-disease common target protein interactions.The common targets were then selected and analyzed by compound-disease common target protein interactions,followed by gene ontology(GO)analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis.Results A total of 152 common targets were screened out,and the common targets were subjected to GO functional analysis and KEGG pathway enrichment analysis to obtain the major pathways.Conclusion The active ingredient in the tonic,slackin,acts on IL6 and other targets through the IL-17 signaling path-way,reflecting the multi-component,multi-target,and multi-pathway treatment of IBS-D in the tonic.
关键词
网络药理学/分子对接/健脾息风汤/肠易激综合征/信号通路/作用机制
Key words
network pharmacology/molecular docking/Jianpi Xifeng decoction/irritable bowel syndrome/signaling pathway/mecha-nism of action
维普
万方数据