Study on the Anti-aging Mechanism of Stewed Polygoni Multiflori Based on UHPLC-QE-MS and Network Pharmacology
Objective To explore the anti-aging mechanism of stewed Polygonum multiflori.Methods Identifying the active ingredients of raw and fermented Polygonum multiflorum using UHPLC-QE-MS technology,screening out the main active ingredients and targets of fermented Polygonum multiflorum using relevant databases,and KEGG enrichment analysis and GO functional analysis were con-ducted using DAVID database.Results A total of 82 effective ingredients were obtained from Polygonum multiflorum,and a total of 40 targets were identified for the treatment of age-related diseases.Obtaining three core targets:AKT1,EGFR,and HIF1A,which are mainly enriched in proteoglycans in cancer and signaling pathways related to cancer formation.Conclusion Stewed Polygonum multiflo-rum mainly exerts anti-aging effects through negative regulation of cell apoptosis process and negative regulation of gene expression.
万方数据
维普
