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博落回的生物碱成分

Alkaloids from Macleaya cordata

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目的:研究博落回Macleaya cordata的生物碱成分.方法:应用多种柱色谱法结合重结晶进行分离纯化,通过理化性质和波谱数据鉴定化合物结构.结果:从博落回中分离并鉴定出13种生物碱,分别鉴定为6-甲氧基二氢血根碱(6-methoxy-dihydrosanguinarine,1),去甲血根碱(norsanguinarine,2),6-丙酮基二氢白屈菜红碱(6-acetonyldihyrochelerythrine,3),6-丙酮基二氢血根碱(6-acetonyldihyrosanguinnarine,4),sanguidimerine(5),chelidimerine(6),(±)-bocconarborine A(7),(±)-bocconarborine B(8),隐品碱(cryptopine,9),二氢血根碱(dihydrosanguinarine,10),二氢白屈菜红碱(dihydrochelerythrine,11),原阿片碱(protopine,12),α-别隐品碱(α-allocryptopine,13).结论:化合物1为首次从博落回中分得,化合物2,3,5～9均为首次从博落回属植物中分得.
Objective: To study the alkaloids of Macleaya cordata. Method: The alkaloids were isolated and purified by various column chromatography as well as recrystallization. Their structures were identified by physico-chemical properties and spectral analysis. Result: Thirteen alkaloids were isolated and identified as 6-methoxy-dihydrosanguinarine (1), norsanguinarine (2), 6-acetonyl-dihyrochelerythrine (3), 6-acetonyl-dihyrosanguinnarine (4), sanguidimerine (5), chelidimerine (6), (±)-bocconarborine A (7) , (±)-bocconarborine B (8) , cryptopine (9) , dihydrosanguinarine (10) , dihydrochelerythrine (11) , protopine (12) ,a-allocryptopine (13). Conclusion; Compounds 2, 3, 5-9 were firstly isolated from the genus Macleaya and compound 1 was obtained from M. cordata for the first time.

Macleaya cordatachemical constituentsisoquinoline alkaloids

叶冯芝、冯锋、柳文媛

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中国药科大学,天然药物化学教研室,江苏,南京,210009

中国药科大学,药物分析教研室,江苏,南京,210009

博落回 化学成分 异喹啉生物碱

2009

中国中药杂志
中国药学会

中国中药杂志

CSTPCDCSCD北大核心
影响因子：1.718
ISSN：1001-5302
年,卷(期)：2009.34(13)
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