蛇石六黄汤对尿路感染及细胞因子影响的研究
Sheshiliuhuang decoction on cytokines in patients with urinary tract infection
丁凡 1张艳春 1畅亦杰2
作者信息
- 1. 呼伦贝尔市海拉尔区传染病医院,内蒙古,海拉尔,021000
- 2. 解放军305医院,北京,100017
- 折叠
摘要
目的:探讨中药蛇石六黄汤对尿路感染(UTI)的临床疗效及细胞因子的影响.方法:将92例尿路感染患者随机分为治疗组47例,对照组45例;治疗组用蛇石六黄汤,1剂/d,分2次口服;对照组给予三金片口服,3片/次,3次/d,7 d为1疗程.观察2组患者治疗前后临床疗效及肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)和白细胞介素8(IL-8)水平.且设正常健康组43例.结果:临床有效率治疗组93.62%,对照组82.22%,差异有显著性(P<0.05).2组治疗前IL-6,IL-8,TNF-α均较健康组高(P<0.01).治疗后治疗组IL-6,TNF-α明显降低,与对照组比差异有显著性(P<0.01),治疗组与治疗前对比差异有显著性P<0.01.结论:尿路感染时细胞因子IL-6,IL-8,TNF-α明显增高.蛇石六黄汤治疗UTI有明显的临床疗效,可能与有效干预IL-6,IL-8,TNF-α因子的释放有关.
Abstract
Objective:To investigate the therapeutic effects of Sheshiliuhuang decoction on clinical outcomes and cytokines in patients with urinary tract infection (UTI).Method:Ninety-two (92) patients were selected and randomly divided into 2 groups,the treatment group (n=47) administered with Sheshiliuhuang decoction,one prescription,2 times a day,while patients in the control group (n=45) were given Sanjin pills,3 pills a time,3 times a day.The treatment lasted for 7 days.Clinical outcomes and serum levels of TNF-α,IL-6,IL-8 in both groups were examined before and after the treatment.Result:The clinical effective rate was 93.62% in the treatment group and 88.22% the control group,indicating a significant difference of P<0.05.Before the treatment,the serum levels of TNF-α,IL-6,IL-8 of treatment group were significantly higher than those in the control group (P<0.05).At the end of the treatment,serum levels of IL-6 and TNF-α in the treatment group were significantly decreased compared with the before treatment (P<0.01) and those did in the control group (P<0.01).Conclusion:Serum cytokines of IL-6,IL-8,and TNF-α were significantly increased in patients with UTI.Sheshiliuhuang decoction,with the mechanisms of regulating IL-6,IL-8,TNF-α,is an effective agent in patients with UTI.
关键词
尿路感染/蛇石六黄汤/细胞因子Key words
urinary tract infection/Sheshiliuhuang decoction/cytokines引用本文复制引用
出版年
2010
国家科技期刊平台
NSTL
维普
万方数据