注射用丹参多酚酸盐联合常规西药治疗稳定型心绞痛研究的疗效及安全性探讨
Efficacy and safety of smiltiorrhizadepsidesal combined with conventional western medicine treatment for stable angina pectoris
李园 1王连心 1谢雁鸣1
作者信息
- 1. 中国中医科学院中医临床基础医学研究所,北京100700
- 折叠
摘要
近年来,国内采用注射用丹参多酚酸盐(smiltiorrhizadepsidesal,SMDS)联合西药治疗稳定型心绞痛(stable angina pectoris,SAP)取得了较好的临床疗效,SMDS是从活血化瘀类中药丹参中提取其水溶性有效成分制备而成,具有活血、化瘀、通脉的作用,用于治疗Ⅰ级和Ⅱ级SAP.通过检索PubMed,EMbase,the Cochrane Library,CNKI,VIP,WanFang Data和CBM数据库对SMDS联合单纯常规西药治疗SAP的疗效及安全性进行探讨.发现SMDS联合常规西药治疗SAP的疗效优于单纯常规西药治疗,也优于丹参注射液、复方丹参注射液等同类中药联合常规西药治疗SAP的疗效;对降低血液粘稠度、动脉粥样硬化、改善微循环方面具有积极作用.临床研究中SMDS联合常规西药治疗SAP的不良反应(adverse drug reaction,ADR)报道与自发呈报系统(spontaneous reporting system,SRS)中发现的SMDS相关ADR预警信号基本一致.总体来看,临床SMDS联合常规西药治疗SAP的ADR发生率较低,无严重ADR发生,安全性较好.目前,马来酸桂哌齐特注射液、果糖二酸钠、盐酸普罗帕酮、盐酸罂粟碱注射液等心血管疾病相关药物与SMDS联合用药存在配伍禁忌,临床使用时应引起高度重视.
Abstract
In recent years,Chinese patent medicines such as smiltiorrhizadepsidesal(SMDS) injection are combined with western medicine to achieve good clinical efficacy for stable angina pectoris(SAP).SMDS is prepared by the water-soluble active ingredients extracted from Salvia miltiorrhiza,with the functions of promoting blood circulation,removing blood stasis and activating blood vessels,and it is used to treat type Ⅰ SAP and type Ⅱ SAP.The efficacy and safety of SMDS combined with simple routine western medicine for SAP were investigated by searching PubMed,EMbase,the Cochrane Library,CNKI,VIP,WanFang Data and CBM Database.SMDS combined with conventional western medicine treatment showed better efficacy for SAP as compared with western medicine alone,and better than other traditional Chinese medicines (such as Danshen injection and compound Danshen injection) combined with conventional western medicine.It was found that SMDS had a positive role in reducing blood viscosity,atherosclerosis,and improving microcirculation.The reported adverse drug reactions (ADRs) of SMDS combined with conventional western medicine therapy in clinical research were basically the same with ADRs reported by spontaneous reporting system(SRS) warning signals.Overall,SMDS combined with conventional western medicine had low incidence of ADR and no serious ADR occurred for SAP treatment in clinical trials.Currently,some drugs related to cardiovascular diseases such as ascinepazidemaleate injection,sodium succinate,propafenone hydrochloride and papaverine hydrochloride injection combined with SMDS have incompatibility,which should be highly emphasized in clinical use.
关键词
注射用丹参多酚酸盐/稳定型心绞痛/联合用药/有效性/安全性/不良反应/配伍禁忌Key words
smiltiorrhizadepsidesal (SMDS)/stable angina pectoris (SAP)/combination/effectiveness/safety/adverse reactions/incompatibility引用本文复制引用
基金项目
北京市中医药科技发展项目(JJ2014-53)
中国中医科学院第九批自主选题项目(20417)
出版年
2016
国家科技期刊平台
NSTL
维普
万方数据