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中药抑制NADPH氧化酶的研究进展

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NADPH氧化酶异常激活生成过量活性氧介导的氧化损伤是多种疾病的病理机制,中药可通过抑制NADPH氧化酶而发挥抗氧化作用,减轻组织、血管、神经等损伤,对于动脉粥样硬化、缺血再灌注、高血压、高血糖等病理状态均有治疗意义.该文对具有NADPH氧化酶抑制作用的中药单体、复方与成药进行综述,以阐释、总结其可能的治疗意义与抑制作用的靶点机制.
Research progress of Chinese herbs inhibiting NADPH oxidase
Oxidative damage mediated by the abnormal activation of NADPH oxidase and the resulting excessive ROS generation is the pathogenesis for various diseases.Chinese herbs can play a role in the antioxidant treatment by inhibiting NADPH oxidase,which is meaningful for the treatment of pathological conditions such as injury of tissues,blood vessels and nerves,atherosclerosis,ischemia reperfusion,hypertension and hyperglycemia.In this paper,different forms of Chinese herbs including monomers,compounds and Chinese patent medicines with the inhibitory effect against NADPH oxidase would be reviewed,in order to explain and generalize their possible functions and the target mechanism for inhibition.

NADPH oxidasereactive oxygen speciesChinese herbs

张青、周俪姗、董慧

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华中科技大学同济医学院附属同济医院中西医结合研究所,湖北武汉430030

华中科技大学同济医学院附属武汉儿童医院(武汉市妇幼保健院)中西医结合科,湖北武汉430016

NADPH氧化酶 活性氧 中药

国家自然科学基金

81403251

2017

中国中药杂志
中国药学会

中国中药杂志

CSTPCDCSCD北大核心
影响因子:1.718
ISSN:1001-5302
年,卷(期):2017.42(23)
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