南五味子属植物的化学成分、药理作用及临床应用研究进展
Research progress on chemical constituents from Kadsura genus and its pharmacological activities and clinical application
苏维 1王欣悦 2付港 3陈武贤 2申湘茹 2李斌 3王炜3
作者信息
- 1. 湖南中医药大学 药学院, 湖南 长沙 410208;湖南中医药大学 中医药民族医药国际联合实验室, 湖南 长沙 410208;湖南中医药大学 期刊杂志社, 湖南 长沙 410208
- 2. 湖南中医药大学 药学院, 湖南 长沙 410208
- 3. 湖南中医药大学 药学院, 湖南 长沙 410208;湖南中医药大学 中医药民族医药国际联合实验室, 湖南 长沙 410208
- 折叠
摘要
五味子科南五味子属Kadsura植物有 29 种,主产于亚洲东部和东南部.在我国分布的南五味子属植物有 10 种,也是主要的药用植物资源类群之一,具有活血止痛、祛风除湿功效,其所含化学成分主要包括木脂素类和三萜类化合物.现代药理和临床研究证明,该属植物的提取物及化学成分具有抗类风湿关节炎、保肝、抗氧化、抗炎等生物活性,也可用于治疗风湿性疾病、肝病等.该文对我国南五味子属植物 2012 年至今新报道的化合物,以及近年来该属植物的药理作用和临床应用进行综述,以期为其进一步的研究开发提供理论基础.
Abstract
The 29 plant species in the Kadsura genus of the Schisandraceae family are mainly distributed in eastern and southeas-tern Asia.Ten species of plants in this genus are distributed in China,some of which are folk medicinal plants with activating blood circulation,relieving pain,dispelling wind,and dehumidifying effects.Their main constituents are lignans and triterpenes.The cur-rent pharmacology and clinical studies have shown that their extracts and constituents have anti-rheumatoid arthritis,liver protection,antioxidation,anti-inflammatory,and other biological activities.The rheumatologic and liver diseases can also be treated with the plants in the clinic.The new chemical constituents reported in the last decade(2012 to date)from the plants of Kadsura genus in Chi-na,as well as their pharmacological effects and clinical applications in recent years were reviewed,so as to provide a theoretical basis for further research on the genus.
关键词
南五味子属/五味子科/木脂素/三萜/抗类风湿关节炎/保肝/抗炎Key words
Kadsura genus/Schisandraceae/lignans/triterpenes/anti-rheumatoid arthritis/liver protection/anti-inflammatory引用本文复制引用
基金项目
国家自然科学基金(82074122)
湖南省大学生创新创业训练计划(2022)(2874)
湖南中医药大学校级科研基金(2022XJZKC018)
出版年
2024
NETL
NSTL
维普
万方数据