Network Meta-analysis of different Chinese medicine injections combined with conventional western medicine in treatment of acute heart failure
This study aims to evaluate the efficacy and safety of Chinese medicine injection in the treatment of acute heart failure.PubMed,Cochrane Library,EMbase,Web of Science,CNKI,VIP,Wanfang,and SinoMed were searched for the randomized con-trolled trial(RCT)of Chinese medicine injection combined with conventional western medicines in the treatment of acute heart failure with the time interval from the inception to July 10,2023.Two researchers independently screened the literature,extracted data,and evaluated the risk of bias in the included studies.Stata 15.1 was used to perform network Meta-analysis.A total of 117 RCTs were in-cluded,involving 10 529 patients and 7 Chinese medicine injections:Shenfu Injection,Shenmai Injection,Danhong Injection,Puera-rin Injection,Xinmailong Injection,Shengmai Injection,and Yiqi Fumai Injection.Network Meta-analysis yielded the following re-sults.① In terms of improving the total response rate,the surface under the cumulative ranking curve(SUCRA)ranking was Sheng-mai Injection + conventional western medicine>Danhong Injection + conventional western medicine>Shenmai Injection + conventio-nal western medicine>Shenfu Injection + conventional western medicine>Xinmailong Injection + conventional western medicine>Yiqi Fumai Injection + conventional western medicine>Puerarin Injection + conventional western medicine>conventional western medicine.②In terms of reducing brain natriuretic peptide(BNP),the SUCRA ranking was Danhong Injection + conventional western medicine>Xinmailong Injection + conventional western medicine>Yiqi Fumai Injection + conventional western medicine>Shenfu In-jection + conventional western medicine>Shenmai Injection + conventional western medicine>Puerarin Injection + conventional wes-tern medicine>Shengmai Injection + conventional western medicine>conventional western medicine.③In terms of reducing N-termi-nal pro-brain natriuretic peptide(NT-proBNP),the SUCRA ranking was Shenmai Injection + conventional western medicine>Yiqi Fumai Injection + conventional western medicine>Xinmailong Injection + conventional western medicine>Shengmai Injection + con-ventional western medicine>Shenfu Injection + conventional western medicine>Puerarin Injection + conventional western medicine>Danhong Injection + conventional western medicine>conventional western medicine.④ In terms of improving the left ventricular ejec-tion fraction(LVEF),the SUCRA ranking was Shenmai Injection + conventional western medicine>Xinmailong Injection + conven-tional western medicine>Shenfu Injection + conventional western medicine>Yiqi Fumai Injection + conventional western medicine>Puerarin Injection + conventional western medicine>Danhong Injection + conventional western medicine>Shengmai Injection + con-ventional western medicine>conventional western medicine.⑤ In terms of decreasing the left ventricular end-diastolic diameter(LVEDD),the SUCRA ranking was Shenmai Injection + conventional western medicine>Shenfu Injection + conventional western medicine=Xinmailong Injection + conventional western medicine>Shengmai Injection + conventional western medicine>Yiqi Fumai Injection + conventional western medicine>conventional western medicine>Puerarin Injection + conventional western medicine.⑥ In terms of increasing the 6-min walk trail(6MWT),the SUCRA ranking was Xinmailong Injection + conventional western medi-cine>Shenfu Injection + conventional western medicine>Shenmai Injection + conventional western medicine>Yiqi Fumai Injection + conventional western medicine>conventional western medicine.⑦ In terms of reducing the Minnesota heart failure quality of life scale(MLHFQ)scores,the SUCRA ranking was Xinmailong Injection + conventional western medicine>Shenmai Injection + conventional western medicine>Shenfu Injection + conventional western medicine>conventional western medicine.⑧In terms of safety,the group of Chinese medicine injection combined with conventional western medicine had lower incidence of adverse reactions than the control group.The current evidence shows that combining Chinese medicine injection with conventional western medicine treatment can im-prove the therapeutic effect on acute heart failure,with high safety.Due to the limited number and quality of included studies,the above conclusions need to be verified by more high-quality studies.
acute heart failureChinese medicine injectionnetwork Meta-analysisclinical effect
NETL
NSTL
万方数据
维普
