黄芪及活性成分治疗肺癌的研究进展
Research progress in Astragali Radix and its active ingredients in treatment of lung cancer
马定财 1王哲 1王毛毛 1张育贵 1王彦钧 1刘婷 1张转红 1高飞云 1李越峰1
作者信息
- 1. 甘肃中医药大学, 甘肃 兰州 730000;甘肃省中药质量与标准研究重点实验室, 甘肃 兰州 730000
- 折叠
摘要
肺癌是癌症死亡原因居于首位的恶性肿瘤,其有效治疗是现代医学难题.肺癌属于中医"肺积""息贲""劳嗽"等范畴,中医药在治疗肺癌方面已积累大量理论基础和实践经验.黄芪是补气药代表之一,黄芪治疗肺癌以"气虚邪滞"为主要证型,"扶正祛邪"为其基本治则.黄芪治疗肺癌的作用机制有抑制肿瘤细胞增殖及促进凋亡、抑制肿瘤侵袭和迁移、调控肿瘤微环境、抗肿瘤血管生成、调节自噬、诱导巨噬细胞极化、增强机体免疫和抑制免疫逃逸、逆转顺铂耐药等.黄芪治疗肺癌的活性成分有多糖类、皂苷类、黄酮类等.该研究从黄芪治疗肺癌的作用机制以及药物成分基础治疗肺癌两大方面进行综述,为黄芪资源及其活性成分的开发利用提供依据,并为抗肿瘤新药研发提供参考.
Abstract
Lung cancer is the leading cause of cancer death,and its effective treatment is a difficult medical problem.Lung cancer belongs to the traditional Chinese medicine(TCM)disease categories of lung accumulation,lung amassment,and overstrain cough.Rich theoretical basis and practical experience have been accumulated in the TCM treatment of lung cancer.Astragali Radix is one of the representatives of Qi-tonifying drugs.It mainly treat the lung cancer with the syndrome of Qi deficiency and pathogen stagnation,following the principle of reinforcing healthy Qi and eliminating patgogenic Qi.Astragali Radix exerts a variety of pharmacological activ-ities in the treatment of lung cancer,including inhibiting tumor cell proliferation and promoting tumor cell apoptosis,inhibiting tumor invasion and migration,regulating the tumor microenvironment,suppressing tumor angiogenesis,modulating autophagy,inducing mac-rophage polarization,enhancing immunity,inhibiting immune escape,and reversing cisplatin resistance.The active ingredients of As-tragali Radix in treating lung cancer include polysaccharides,saponins,and flavonoids.This study reviewed the pharmacological activi-ties and active ingredients of Astragali Radix in the treatment of lung cancer,providing a basis for the development and utilization of Astragali Radix resources and active ingredients and the research and development of anti-tumor drugs.
关键词
黄芪/活性成分/肺癌/药理活性/调节自噬/调控肿瘤微环境/逆转顺铂耐药Key words
Astragali Radix/active ingredients/lung cancer/pharmacological activity/regulating autophagy/improve the tumor microenvironment/reverse cisplatin resistance引用本文复制引用
基金项目
国家自然科学基金项目(81960713)
国家自然科学基金项目(82160750)
甘肃省教育厅产业支撑计划项目(2021CYZC-21)
甘肃中医药大学2023年研究生创新创业基金项目()
甘肃省科学技术厅-科技计划(创新基地与人才计划)基础研究创新群体项目(21JR7RA569)
甘肃省教育厅双一流重大科研项目(GSSYLXM-05)
出版年
2024
NETL
NSTL
维普
万方数据