首页|巨噬细胞极化在肺部疾病中的作用机制及中药的干预

巨噬细胞极化在肺部疾病中的作用机制及中药的干预

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巨噬细胞作为机体重要的免疫细胞,是参与维持肺内微环境稳态的关键因素,由于其高度的可塑性,可在不同的条件下极化为不同的亚型:经典活化巨噬细胞M1 和选择性活化巨噬细胞M2,两者分别具有促炎和抗炎作用.M1/M2 表型与肺部疾病的发生发展密切相关,在巨噬细胞极化过程中涉及的多种信息分子和细胞因子在各种肺部疾病中均有重要的调控表型的作用,且在不同疾病中表型的转换也存在明显差异.该文主要通过综述巨噬细胞极化生物学特性,探讨巨噬细胞极化在支气管哮喘、慢性阻塞性肺疾病、急性肺损伤、肺纤维化等肺部疾病中的作用特点和以调控巨噬细胞极化为靶点的中药单体及中药复方对相关疾病的研究进展,旨在挖掘巨噬细胞极化在调控肺部炎症方面的潜力,为相关临床研究提供新思路.
Role of macrophage polarization in pulmonary diseases and intervention of traditional Chinese medicines
As important immune cells,macrophages are a key factor involved in maintaining the homeostasis of the pulmonary microenvironment.Under different conditions,macrophages with high plasticity can be polarized into classically activated(M1)and selectively activated(M2)macrophages,which have pro-inflammatory and anti-inflammatory effects,respectively.M1/M2 phenotype is associated with the occurrence and development of pulmonary diseases.A variety of information molecules and cytokines involved in the polarization of macrophages play a role in regulating phenotypes in pulmonary diseases,and the phenotype transformation varies significantly in different diseases.This paper introduces the biological characteristics of macrophage polarization and expounds the roles of macrophage polarization in bronchial asthma,chronic obstructive pulmonary disease,acute lung injury,and pulmonary fibrosis.Moreover,the research progress in the regulation of macrophage polarization by the active components in traditional Chinese medicine(TCM)and the TCM compound prescriptions in the treatment of pulmonary diseases was reviewed.This review aims to explore the potential of macrophage polarization in regulating pulmonary inflammation and provide new ideas for related clinical research.

macrophage polarizationM1 macrophagesM2 macrophagespulmonary diseasestraditional Chinese medicine

梁晓、刘建勋

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中国中医科学院 西苑医院 基础医学研究所 国家中医心血管病研究中心中药药理北京市重点实验室, 北京 100091

巨噬细胞极化 M1 型巨噬细胞 M2 型巨噬细胞 肺部疾病 中药

国家自然科学基金重点项目国家自然科学基金重点项目中国中医科学院科技创新工程项目国家中医药管理局中医药传承与创新"百千万"人才工程(岐黄工程)岐黄学者项目

8203012482174015CI2021A04609

2024

10.19540/j.cnki.cjcmm.20230911.701

中国中药杂志
中国药学会

中国中药杂志

CSTPCD北大核心
影响因子：1.718
ISSN：1001-5302
年,卷(期)：2024.49(2)
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