首页|进程管理的微波真空干燥工艺在中药临方浸膏干燥中的应用研究

进程管理的微波真空干燥工艺在中药临方浸膏干燥中的应用研究

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中药浸膏作为中药制剂的重要中间体,其干燥效果直接影响制剂后续的生产过程,因而其是影响最终的药品质量的重要因素.为满足中药临方制剂"高载药、时效性及工艺简便"的要求,该研究探索了进程管理的微波真空干燥工艺在中药临方浸膏干燥中的应用研究.对5种辅料及40个中药处方进行微波真空干燥工艺影响因素考察.以干燥的可行性、干燥速率、干燥时间以及干膏状态为指标,考察微波真空干燥的进料要求;以干燥后干膏状态为评价指标,对3种干燥程序组(A、B、C)进行对比研究,获得最优干燥方法.实验结果表明微波真空干燥最优进料条件为料层厚度2 cm;优选干燥方法为C组程序(共7个干燥进程),以进程管理的策略解决了微波干燥易焦糊的问题,同时发现微波干燥程序中的预设干浸膏含水率应在4％～5％,可以获得质量均一,干燥完全,且没有焦糊的中药干浸膏.该研究为微波干燥在中药临方生产中的应用奠定了基础,从而推动了中药临方制剂的高质量发展.
Application of microwave vacuum drying with process management in extract drying of personalized traditional Chinese medicine preparations
Extracts are important intermediates in the production of traditional Chinese medicines preparations.The drying effect of extracts will directly affect the subsequent production process and the quality of the preparation.To meet the requirements of high drug loading,short time consumption,and simple production process of personalized traditional Chinese medicine preparations,this study explored the application of multi-program microwave vacuum drying process in the extract drying of personalized traditional Chinese medicine preparations.The influencing factors of micro wave vacuum drying process were investigated for 5 excipients and 40 prescriptions.Taking the feasibility of drying,drying rate,drying time,and dried extract status as indicators,this study investigated the feeding requirements of microwave vacuum drying.With the dried extract status as the evaluation indicator,the three drying programs(A,B,and C)were compared to obtain the optimal drying condition.The experimental results showed that the optimal feeding conditions for microwave vacuum drying were material layer thickness of 2 cm and C program(a total of 7 drying processes),which solved the problem of easy scorching in microwave drying with process management.Furthermore,the preset moisture content of the dried extract in microwave drying should be 4％-5％,so that the dried extract of traditional Chinese medicine preparation had uniform quality,complete drying,and no scorching.This study lays a foundation for the application of microwave drying in the production of traditional Chinese medicine preparations,promoting the high-quality development of personalized traditional Chinese medicine preparations.

microwave vacuum dryingpersonalized traditional Chinese medicine preparationdrying of extractsmoisture content

董育瑄、李益萍、洪燕龙、林晓、王优杰

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上海中医药大学创新中药研究院,上海 201203

上海中医药大学中药现代制剂技术教育部工程研究中心,上海 201203

上海中医药大学中药学院,上海 201203

上海中医药大学上海中医健康服务协同创新中心,上海 201203

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微波真空干燥 中药临方制剂 浸膏干燥 含水率

国家自然科学基金上海市"科技创新行动计划"技术标准项目上海中医药慢性病防治与健康服务省部共建协同创新中心项目上海市自然科学基金上海市自然科学基金

8197349020DZ22009002021科技02-3720ZR145840023ZR1463500

2024

10.19540/j.cnki.cjcmm.20231107.301

中国中药杂志
中国药学会

中国中药杂志

CSTPCD北大核心
影响因子：1.718
ISSN：1001-5302
年,卷(期)：2024.49(3)
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