首页|中药临方热熔压敏胶贴膏剂的成型基质处方研究

中药临方热熔压敏胶贴膏剂的成型基质处方研究

Molding matrix formulation of hot-melt pressure-sensitive adhesive plaster of personalized traditional Chinese medicine preparations

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优选中药临方热熔压敏胶贴膏剂的基质处方,得到中药临方热熔压敏胶贴膏剂通用成型基质处方,并验证贴膏成型基质处方的适用性.采用JMP Pro 16.1.0中心复合设计试验法,以苯乙烯-异戊二烯-苯乙烯嵌段共聚物(styrene-isoprene-sty-rene triblock copolymer,SIS)、氢化石油树脂、轻质液体石蜡不同用量进行试验,以中药益脾方细粉为模型药物(载药量10％),以感官评分和客观评价为综合评价指标,建立中药临方热熔压敏胶贴膏剂质量评价体系,优化中药临方热熔压敏胶贴膏剂的成型基质处方.选取16种中药贴膏剂处方对优化后的热熔压敏胶贴膏成型基质处方的适用性进行验证,并通过对不同载药量的考察对热熔胶贴膏成型基质处方的适用性进行进一步研究.热熔压敏胶型中药贴膏剂的通用成型基质处方中基质用量比例为SIS-氢化石油树脂-轻质液体石蜡3∶3∶5.以优化后的成型基质处方所制成的16种模型中药热熔压敏胶贴膏剂成型性好、质量评分较高,并适用于10％～30％载药量的饮片细粉贴膏,提示优化的成型基质处方有较好的适用性,为中药临方热熔压敏胶贴膏剂的应用和推广奠定基础.
This study aims to optimize the matrix formulation for the hot-melt pressure-sensitive adhesive plaster of personalized traditional Chinese medicine(TCM)preparations and verify the applicability of the formulation.The central composite design in JMP Pro 16.1.0 was employed to optimize the dosages of styrene-isoprene-styrene triblock copolymer(SIS),hydrogenated petroleum resin,and lightweight liquid paraffin,with the fine powder of Yipifang as the model drug(drug loading of 10％)and the sensory score and objective evaluation as the comprehensive evaluation indicators.The quality evaluation system of hot-melt pressure-sensitive adhesive plaster of personalized TCM preparations was established.The applicability of the optimized matrix formulation of hot-melt pressure-sensitive adhesive plaster was verified with 16 TCM preparations for external application.Furthermore,the applicability of the matrix formulation was investigated with different drug loadings.The general molding matrix formulation was SIS∶hydrogenated petroleum resin:lightweight liquid paraffin 3∶3∶5.The optimized matrix formulation showed good molding properties and high quality scores for 16 TCM preparations and were suitable for the plastering of finely powdered decoction pieces with a loading capacity of 10％to 30％.The results suggest that the optimized matrix formulation has good applicability and is suitable for TCM preparations.The findings lay a foundation for the application and promotion of the hot-melt pressure-sensitive adhesive plasters of personalized TCM preparations.

personalized traditional Chinese medicine preparationshot-melt pressure-sensitive adhesivetraditional Chinese medi-cine plastermolding matrix formulation

赵艳、田文秀、李文杰、沈岚、洪燕龙

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上海中医药大学中药学院,上海 201203

上海中医药大学上海中医健康服务协同创新中心,上海 201203

中药现代制剂技术教育部工程研究中心,上海 201203

中药临方制剂 热熔压敏胶 中药贴膏剂 成型基质处方

国家自然科学基金上海市"科技创新行动计划"技术标准项目上海中医药慢性病防治与健康服务省部共建协同创新中心项目上海市自然科学基金面上项目

8197349020DZ22009002021科技02-3723ZR1463500

2024

10.19540/j.cnki.cjcmm.20231121.302

中国中药杂志
中国药学会

中国中药杂志

CSTPCD北大核心
影响因子：1.718
ISSN：1001-5302
年,卷(期)：2024.49(3)
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