Quorum sensing system regulates the expression of genes related to bacterial growth,metabolism and other behaviors by sensing bacterial density,and controls the unified action of the entire bacterial population.This mechanism can ensure the normal se-cretion of bacterial metabolites and the stability of the biofilm microenvironment,providing protection for the formation of biofilms and the normal growth and reproduction of bacteria.Traditional Chinese medicine,capable of quorum sensing inhibition,can inhibit the formation of bacterial biofilms,reduce bacterial resistance,and enhance the anti-infection ability of antibiotics when combined with an-tibiotics.In recent years,the combination of traditional Chinese and Western medicine in the treatment of drug-resistant bacterial infec-tions has become a research hotspot.Starting with the associations between quorum sensing,biofilm and drug-resistant bacteria,this paper reviews the relevant studies about the combined application of traditional Chinese medicines as quorum sensing inhibitors with an-tibiotics in the treatment of drug-resistant bacteria.This review is expected to provide ideas for the development of new clinical treat-ment methods and novel anti-infection drugs.
关键词
中西药联用/耐药细菌/群体感应系统/生物膜/协同抑制
Key words
combination of traditional Chinese and Western medicine/drug-resistant bacteria/quorum sensing system/biofilm/synergistic inhibition
维普
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