首页|中药作为群体感应抑制剂协同抗生素抑制耐药细菌的研究进展

中药作为群体感应抑制剂协同抗生素抑制耐药细菌的研究进展

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群体感应系统通过感知细菌密度来调节与其生长、代谢等行为相关基因的表达,操控整个细菌群体统一行动,来保证细菌代谢产物的正常分泌和生物膜微环境的稳定,为生物膜形成和细菌的正常生长繁殖提供保障.中药具有群体感应抑制作用,可抑制细菌生物膜的形成,降低细菌耐药性,与抗生素联用能增强抗生素的抗感染能力.近年来,中西药联用治疗耐药细菌感染已成研究热点,该文从群体感应、生物膜与耐药细菌的关联入手,并对将中药作为群体感应抑制剂与抗生素协同抑制耐药细菌的国内外相关研究进行整理归纳,旨在为临床新治疗方式和新型抗感染药物的研发提供思路.
Research progress of traditional Chinese medicines as quorum sensing inhibitors in collaboration with antibiotics to inhibit drug-resistant bacteria
Quorum sensing system regulates the expression of genes related to bacterial growth,metabolism and other behaviors by sensing bacterial density,and controls the unified action of the entire bacterial population.This mechanism can ensure the normal se-cretion of bacterial metabolites and the stability of the biofilm microenvironment,providing protection for the formation of biofilms and the normal growth and reproduction of bacteria.Traditional Chinese medicine,capable of quorum sensing inhibition,can inhibit the formation of bacterial biofilms,reduce bacterial resistance,and enhance the anti-infection ability of antibiotics when combined with an-tibiotics.In recent years,the combination of traditional Chinese and Western medicine in the treatment of drug-resistant bacterial infec-tions has become a research hotspot.Starting with the associations between quorum sensing,biofilm and drug-resistant bacteria,this paper reviews the relevant studies about the combined application of traditional Chinese medicines as quorum sensing inhibitors with an-tibiotics in the treatment of drug-resistant bacteria.This review is expected to provide ideas for the development of new clinical treat-ment methods and novel anti-infection drugs.

combination of traditional Chinese and Western medicinedrug-resistant bacteriaquorum sensing systembiofilmsynergistic inhibition

刘新越、李晨铭、吕春晓、李自强、黄宇虹

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天津中医药大学,天津 301617

天津中医药大学第二附属医院,天津 300250

中西药联用 耐药细菌 群体感应系统 生物膜 协同抑制

国家自然科学基金天津市教委科研项目天津市教委科研项目天津市研究生科研创新项目天津中医药大学研究生科研创新项目

823742502021ZD0172022ZD0512022BKY192YJSKC-20221018

2024

10.19540/j.cnki.cjcmm.20231127.601

中国中药杂志
中国药学会

中国中药杂志

CSTPCD北大核心
影响因子：1.718
ISSN：1001-5302
年,卷(期)：2024.49(3)
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