脓毒症诱导肝损伤的致病机制和中药及其有效成分治疗研究进展
Research progress on pathogenic mechanism of sepsis-induced liver injury and treatment with traditional Chinese medicine and its active components
尹艳萍 1牟菲 2尹艳丽 3赵瑾怡 2龚蕊 2张璐璐 4陈锦仪 5李旺廷 5王婧雯2
作者信息
- 1. 西北大学生命科学学院,陕西西安 710069;空军军医大学西京医院药剂科,陕西西安 710032
- 2. 空军军医大学西京医院药剂科,陕西西安 710032
- 3. 浙江赛默制药有限公司,浙江金华 321000
- 4. 空军军医大学西京医院药剂科,陕西西安 710032;陕西中医药大学药学院,陕西咸阳 712046
- 5. 陕西中医药大学药学院,陕西咸阳 712046
- 折叠
摘要
脓毒症是一种由感染引起的全身炎症反应综合征,发病率和病死率高.脓毒症诱导的肝损伤(sepsis-induced liver injury,SILI)是脓毒症诱发的多器官综合征的表现之一.目前针对SILI的治疗尚无推荐的药理干预措施,而中医药基于整体观及辨证论治理念治疗SILI,体现出多靶点、多通路的治疗特点,可通过干预炎性因子及炎症信号通路、抗氧化应激、抑制细胞凋亡等全面防治SILI.该文通过回顾总结中医药治疗SILI的实验研究,明确其致病机制和治疗特点,以期为研发或制备新药提供更多的思路和方向.
Abstract
Sepsis is a systemic inflammatory response syndrome caused by infection,with high morbidity and mortality.Sepsis-induced liver injury(SILI)is one of the manifestations of sepsis-induced multiple organ syndrome.At present,there is no recommended pharmacological intervention for the treatment of SILI.traditional Chinese medicine(TCM),based on the holism and dialectical treatment concept,shows the therapeutic characteristics of multi-target and multi-pathway and can comprehensively prevent and treat SILI by interfering with inflammatory factors,inflammatory signaling pathways,and anti-oxidative stress and inhibiting apoptosis.This article reviewed the experimental studies on the treatment of SILI with TCM to clarify its pathogenic mechanism and therapeutic characteristics,so as to provide more ideas and directions for the development or preparation of new drugs.
关键词
脓毒症/肝损伤/致病机制/中药及其有效成分/研究进展Key words
sepsis/liver injury/pathogenic mechanism/traditional Chinese medicine and its active components/research progress引用本文复制引用
基金项目
国家自然科学基金(81903837)
国家自然科学基金(81774190)
国家自然科学基金(72074218)
出版年
2024
NETL
NSTL
万方数据