Role of NLRP3 inflammasome in prevention and treatment of cognitive impairment-related diseases and traditional Chinese medicine intervention:a review
Alzheimer's disease(AD),vascular dementia(VD),and traumatic brain injury(TBI)are more common cognitive im-pairment diseases characterized by high disability and mortality rates,imposing a heavy burden on individuals and their families.Al-though AD,VD,and TBI have different specific mechanisms,their pathogenesis is closely related to the nucleotide-binding oligome-rization domain-like receptor protein 3(NLRP3).The NLRP3 inflammasome is involved in neuroinflammatory responses,mediating microglial polarization,regulating the reduction of amyloid β-protein(Aβ)deposition,neurofibrillary tangles(NFTs)formation,auto-phagy regulation,and maintaining brain homeostasis,and synaptic stability,thereby contributing to the development of AD,VD,and TBI.Previous studies have shown that traditional Chinese medicine(TCM)can alleviate neuroinflammation,promote microglial polari-zation towards the M2 phenotype,reduce Aβ deposition and NFTs formation,regulate autophagy,and maintain brain homeostasis by intervening in NLRP3 inflammasome,hence exerting a role in preventing and treating cognitive impairment-related diseases,reducing psychological and economic pressure on patients,and improving their quality of life.Therefore,this article elucidated the role of NL-RP3 inflammasome in AD,VS,and TBI,and provided a detailed summary of the latest research results on TCM intervention in NLRP3 inflammasome for the prevention and treatment of these diseases,aiming to inherit the essence of TCM and provide references and foun-dations for clinical prevention and treatment of cognitive impairment-related diseases with TCM.Meanwhile,this also offers insights and directions for further research in TCM for the prevention and treatment of cognitive impairment-related diseases.
NLRP3 inflammasomeAlzheimer's diseasevascular dementiatraumatic brain injurycognitive impairmenttradi-tional Chinese medicine(TCM)
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