Interaction between central nervous system and immune system after ischemic stroke and its therapeutic significance of traditional Chinese medicine
Ischemic stroke is divided into acute phase,subacute phase,and recovery phase,with different pathological and physio-logical characteristics manifested at each stage.Among them,immune and inflammatory reactions persist for several days and weeks af-ter ischemia.Ischemic stroke not only triggers local inflammation in damaged brain regions but also induces a disorder in the immune system,thereby promoting neuroinflammation and exacerbating brain damage.Therefore,conducting an in-depth analysis of the inter-action between the central nervous system and the immune system after ischemic stroke,intervening in the main factors of the interac-tion between them,blocking pathological cascades,and thereby reducing brain inflammation have become the treatment strategies for ischemic stroke.This study summarizes and sorts out the interaction pathways between the central nervous system and the immune sys-tem.The impact of the central nervous system on the immune system can be analyzed from the perspective of the autonomic nervous system,the hypothalamic-pituitary-adrenal axis(HPA),and local inflammatory stimulation.The impact of the immune system on the central nervous system can be analyzed from the dynamic changes of immune cells.At the same time,the relevant progress in the pre-vention and treatment of traditional Chinese medicine(TCM)is summarized,so as to provide new insights for the analysis of complex mechanisms of TCM in preventing and treating ischemic stroke.
ischemic strokeimmunity and inflammationcentral nervous systemimmune system
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