首页|中医药调控NLRP3炎症小体缓解糖尿病肾病肾间质纤维化的机制研究进展

中医药调控NLRP3炎症小体缓解糖尿病肾病肾间质纤维化的机制研究进展

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糖尿病肾病(diabetic nephropathy，DN)是一种因糖尿病诱发的进行性慢性肾脏病(chronic kidney disease，CKD)，是终末期肾病的主要病因。肾间质纤维化(renal interstitial fibrosis，RIF)是DN肾功能进展、恶化的不可逆因素。慢性炎症反应已成为DN-RIF发病机制中的关键一环，NOD样受体热蛋白结构域相关蛋白3(NOD-like receptor thermal protein domain associated protein 3，NLRP3)炎症小体作为重要的炎症调节因子，受多种信号调节，促进促炎性因子的产生，诱导肾脏炎症细胞浸润参与肾纤维化进程，其作用机制复杂。目前已有大量中医药实验研究证明了中医药可通过调控NLRP3炎症小体的相关通路减轻炎症反应，进而延缓DN-RIF进展，改善肾功能。该文就NLRP3炎症小体与DN-RIF的关系及中医药干预NLRP3炎症小体缓解DN-RIF机制研究进展进行综述，旨在为DN-RIF靶向治疗提供新的思路。
Mechanism of traditional Chinese medicine in regulating NLRP3 inflammasomes to alleviate renal interstitial fibrosis in diabetic nephropathy:a review
Diabetic nephropathy(DN),a progressive chronic kidney disease(CKD)induced by diabetes mellitus,is the main cause of end-stage renal disease.Renal interstitial fibrosis(RIF)is an irreversible factor in the progression and deterioration of the re-nal function in DN.Chronic inflammation has become a key link in the pathogenesis of DN-RIF.The NOD-like receptor thermal pro-tein domain associated protein 3(NLRP3)inflammasome is an important inflammatory regulator regulated by a variety of signals.It promotes the production of pro-inflammatory cytokines and induces renal inflammatory cell infiltration to participate in the process of re-nal fibrosis,demonstrating a complex mechanism of action.In view of the important role of NLRP3 inflammasomes in the prevention and treatment of DN-RIF,a large number of experimental studies have demonstrated that traditional Chinese medicine(TCM)can re-duce the inflammation by regulating the pathways involving NLRP3 inflammasome,thereby slowing down the progression of DN-RIF and improving the renal function.This paper reviews the relationship between NLRP3 inflammasomes and DN-RIF,and the research pro-gress in the mechanism of TCM intervention in NLRP3 inflammasomes to alleviate DN-RIF,aiming to provide new ideas for the targeted treatment of DN-RIF.

NOD-like receptor thermal protein domain associated protein 3(NLRP3)diabetic nephropathyrenal interstitial fi-brosistraditional Chinese medicineinflammation

乔琳、金艳、郭兆安

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山东中医药大学中医学院,山东 济南 250014

济南市中医医院 肾病科,山东 济南 250002

山东中医药大学附属医院 肾内科,山东济南 250014

NOD样受体热蛋白结构域相关蛋白3(NLRP3) 糖尿病肾病 肾间质纤维化 中医药 炎症

山东省自然科学基金创新发展联合基金

ZR2022LZY005

2024

10.19540/j.cnki.cjcmm.20231123.401

中国中药杂志
中国药学会

中国中药杂志

CSTPCD北大核心
影响因子：1.718
ISSN：1001-5302
年,卷(期)：2024.49(5)
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