摘要
采用大孔树脂、硅胶、葡聚糖凝胶、高效液相等色谱手段,对中药血竭的化学成分进行初步研究,分离得到1个反式二氢查耳酮类、4个黄烷类和1个二苯乙烯类化合物.通过现代波谱学、理化性质和文献比对鉴定其化学结构,分别鉴定为4-羟基-2,6-二甲氧基-3-甲基二氢查耳酮(1)、4'-羟基-5,7-二甲氧基-8-甲基黄烷(2)、7-羟基-4',5-二甲氧基黄烷(3)、(2S)-7-羟基-5-甲氧基-6-甲基黄烷(4)、(2S)-7-羟基-5-甲氧基黄烷(5)、紫檀芪(6),其中化合物1为新化合物,化合物2和6为从棕榈科中首次分离得到.化合物5具有防治糖尿病肾脏疾病的潜力.
Abstract
The chemical constituents of Draconis Sanguis were preliminarily studied by macroporous resin,silica gel,dextran gel,and high-performance liquid chromatography.One retro-dihydrochalcone,four flavonoids,and one stilbene were isolated.Their chemi-cal structures were identified as 4-hydroxy-2,6-dimethoxy-3-methyldihydrochalcone(1),4'-hydroxy-5,7-dimethoxy-8-methylflavan(2),7-hydroxy-4',5-dimethoxyflavan(3),(2S)-7-hydroxy-5-methoxy-6-methylflavan(4),(2S)-7-hydroxy-5-methoxyflavan(5),and pterostilbene(6)by modern spectroscopy,physicochemical properties,and literature comparison.Compound 1 was a new com-pound.Compounds 2 and 6 were first found in the Arecaceae family.Compound 5 had the potential to prevent and treat diabetic kidney disease.
基金项目
国家重点研发计划(2020YFE0201800)
河南省高等学校科技创新人才支持计划(23HASTIT044)
河南省科技攻关计划(232102310447)
河南省高等学校科技创新团队支持计划(21IRTSTHN026)
NETL
NSTL
万方数据