首页|血竭化学成分及其糖尿病肾脏疾病肾小管损伤保护作用评价

血竭化学成分及其糖尿病肾脏疾病肾小管损伤保护作用评价

Evaluation of chemical constituents of Draconis Sanguis and its protective effect on renal tubular injury in diabetic kidney disease

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采用大孔树脂、硅胶、葡聚糖凝胶、高效液相等色谱手段,对中药血竭的化学成分进行初步研究,分离得到1个反式二氢查耳酮类、4个黄烷类和1个二苯乙烯类化合物.通过现代波谱学、理化性质和文献比对鉴定其化学结构,分别鉴定为4-羟基-2,6-二甲氧基-3-甲基二氢查耳酮(1)、4'-羟基-5,7-二甲氧基-8-甲基黄烷(2)、7-羟基-4',5-二甲氧基黄烷(3)、(2S)-7-羟基-5-甲氧基-6-甲基黄烷(4)、(2S)-7-羟基-5-甲氧基黄烷(5)、紫檀芪(6),其中化合物1为新化合物,化合物2和6为从棕榈科中首次分离得到.化合物5具有防治糖尿病肾脏疾病的潜力.
The chemical constituents of Draconis Sanguis were preliminarily studied by macroporous resin,silica gel,dextran gel,and high-performance liquid chromatography.One retro-dihydrochalcone,four flavonoids,and one stilbene were isolated.Their chemi-cal structures were identified as 4-hydroxy-2,6-dimethoxy-3-methyldihydrochalcone(1),4'-hydroxy-5,7-dimethoxy-8-methylflavan(2),7-hydroxy-4',5-dimethoxyflavan(3),(2S)-7-hydroxy-5-methoxy-6-methylflavan(4),(2S)-7-hydroxy-5-methoxyflavan(5),and pterostilbene(6)by modern spectroscopy,physicochemical properties,and literature comparison.Compound 1 was a new com-pound.Compounds 2 and 6 were first found in the Arecaceae family.Compound 5 had the potential to prevent and treat diabetic kidney disease.

Draconis Sanguischemical constituentrenal tubulediabetic kidney disease

周露、段亚飞、王奕航、任尧、张效威、李汉伟、张振强、徐江雁、王潘

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河南中医药大学中医药科学院,河南郑州 450046

河南中医药大学药学院,河南郑州 450046

血竭 化学成分 肾小管 糖尿病肾脏疾病

国家重点研发计划河南省高等学校科技创新人才支持计划河南省科技攻关计划河南省高等学校科技创新团队支持计划

2020YFE020180023HASTIT04423210231044721IRTSTHN026

2024

中国中药杂志
中国药学会

中国中药杂志

CSTPCD北大核心
影响因子:1.718
ISSN:1001-5302
年,卷(期):2024.49(5)
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