Evaluation of chemical constituents of Draconis Sanguis and its protective effect on renal tubular injury in diabetic kidney disease
The chemical constituents of Draconis Sanguis were preliminarily studied by macroporous resin,silica gel,dextran gel,and high-performance liquid chromatography.One retro-dihydrochalcone,four flavonoids,and one stilbene were isolated.Their chemi-cal structures were identified as 4-hydroxy-2,6-dimethoxy-3-methyldihydrochalcone(1),4'-hydroxy-5,7-dimethoxy-8-methylflavan(2),7-hydroxy-4',5-dimethoxyflavan(3),(2S)-7-hydroxy-5-methoxy-6-methylflavan(4),(2S)-7-hydroxy-5-methoxyflavan(5),and pterostilbene(6)by modern spectroscopy,physicochemical properties,and literature comparison.Compound 1 was a new com-pound.Compounds 2 and 6 were first found in the Arecaceae family.Compound 5 had the potential to prevent and treat diabetic kidney disease.
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