Mechanism of traditional Chinese medicine in treating ulcerative colitis-related colorectal cancer by regulating NF-κB-related signaling pathways:a review
Ulcerative colitis is a chronic,recurrent,and nonspecific intestinal inflammatory disease,which is difficult to cure and has the risk of deterioration into related tumors.Long-term chronic inflammatory stimulation can increase the risk of cancerization.With the signaling pathway as a key link in the regulation of tumor microenvironments,nuclear factor-kappa B(NF-κB)is an important regulator of intestinal inflammation.It can also be co-regulated as downstream factors of other signaling pathways,such as TLR4,MAPK,STAT,PI3K,and so on.At present,a large number of animal experiments have proved that traditional Chinese medicine(TCM)can reduce inflammation by interfering with NF-κB-related signaling pathways,improve intestinal inflammation,and inhibit the progression of inflammation to tumors.This article reviewed the relationship between NF-κB-related signaling pathways and the intervention mechanism of TCM,so as to provide a reference for the clinical treatment of ulcerative colitis and the optimization of related cancer prevention strategies.
ulcerative colitisUCRCCNF-κBtraditional Chinese medicine
NETL
NSTL
万方数据
