中医药调控NF-κB相关信号通路干预溃疡性结肠炎相关性癌变的研究进展
Mechanism of traditional Chinese medicine in treating ulcerative colitis-related colorectal cancer by regulating NF-κB-related signaling pathways:a review
张钰异 1王浩 1王思琳 1周春航 1宋宁宁 2程丽敏2
作者信息
- 1. 黑龙江中医药大学, 黑龙江 哈尔滨 150040
- 2. 黑龙江中医药大学 第一附属医院, 黑龙江 哈尔滨 150040
- 折叠
摘要
溃疡性结肠炎是以慢性、反复发作性和非特异性为特征的肠道炎症疾病,难以治愈,并有恶化为相关性肿瘤的风险,长期持续的慢性炎症刺激能增加癌变的风险,信号途径作为调节肿瘤微环境的关键一环,核因子-κB(NF-κB)不仅是肠道炎症重要的调节因子,还能作为其他信号途径的下游因子来共同调节,如TLR4、MAPK、STAT、PI3K等途径.目前已有大量动物实验研究证明了中药可通过干预NF-κB相关信号通路减轻炎症反应,改善肠道炎症,进而抑制炎症向肿瘤的进展.该文就NF-κB相关串扰通路关系及中医药对其干预机制的研究作一综述,以期为临床溃疡性结肠炎治疗及相关性癌变预防策略的优化提供借鉴与参考.
Abstract
Ulcerative colitis is a chronic,recurrent,and nonspecific intestinal inflammatory disease,which is difficult to cure and has the risk of deterioration into related tumors.Long-term chronic inflammatory stimulation can increase the risk of cancerization.With the signaling pathway as a key link in the regulation of tumor microenvironments,nuclear factor-kappa B(NF-κB)is an important regulator of intestinal inflammation.It can also be co-regulated as downstream factors of other signaling pathways,such as TLR4,MAPK,STAT,PI3K,and so on.At present,a large number of animal experiments have proved that traditional Chinese medicine(TCM)can reduce inflammation by interfering with NF-κB-related signaling pathways,improve intestinal inflammation,and inhibit the progression of inflammation to tumors.This article reviewed the relationship between NF-κB-related signaling pathways and the intervention mechanism of TCM,so as to provide a reference for the clinical treatment of ulcerative colitis and the optimization of related cancer prevention strategies.
关键词
溃疡性结肠炎/溃疡性结肠炎相关性癌(UCRCC)/NF-κB/中医药Key words
ulcerative colitis/UCRCC/NF-κB/traditional Chinese medicine引用本文复制引用
基金项目
黑龙江省自然科学基金项目(H201480)
出版年
2024
NETL
NSTL
万方数据