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薏苡仁活性成分研究进展

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薏苡仁作为我国常用的一种药食同源资源,种植与药用历史悠久.中医认为,薏苡仁具有健脾补肺、清热利湿、排脓除痹、止泻等功效,用来治疗水肿、脚气、脾虚泄泻等症,上述功效与其含有多种活性成分密切相关,如酯类及脂肪酸类、多糖类、蛋白质类,以及酚酸、甾醇、黄酮、内酰胺、三萜、生物碱、腺苷等.现代研究发现,薏苡仁还具有抗癌、抗炎、抗氧化、降血糖、降血压、提高免疫力、调节血脂代谢等多种药理活性.薏苡仁在我国分布广泛,主产于贵州、云南、福建、四川等地,各产地薏苡仁质量参差不齐.从古至今,薏苡仁炮制方法经历了由简到繁的过程,辅料的种类也越来越广泛,如土、麸、河砂等,这些炮制方法历代传承,如今常用的为麸炒、清炒、砂炒法等.该文通过查阅近几年国内外相关文献,对薏苡仁主要活性成分及相关药理作用进行梳理概括,总结不同产地与炮制方法对薏苡仁化学成分差异的影响,以期为薏苡仁的综合开发利用和进一步作用机制研究提供参考.
Research progress on active ingredients of Coicis Semen
As a common medicinal and edible resource in China,Coicis Semen has a long history of cultivation and medicinal use.Traditional Chinese medicine(TCM)clinically believes that Coicis Semen has the effect of strengthening the spleen and tonifying the lungs,clearing heat and dampness,removing pus and paralysis,and stopping diarrhea.Therefore,it is used to treat edema,foot odor,spleen deficiency,diarrhea,and other symptoms.The above effects are closely related to the active ingredients of Coicis Semen,such as esters,fatty acids,polysaccharides,proteins,as well as phenolic acids,sterols,flavonoids,lactams,triterpenes,alkaloids,and adenosine.Modern research has found that Coicis Semen also has anti-cancer,anti-inflammatory,antioxidant,hypoglycemic,and hy-potensive effects and other pharmacological activities,and it can improve immunity and regulate lipid metabolism.Coicis Semen is widely distributed in China,mainly produced in Guizhou,Yunnan,Fujian,Sichuan,and other places,and the quality of Coicis Se-men from different origins varies.From ancient times to the present,Coicis Semen processing methods have experienced the process from simple to complex,and the types of auxiliary materials are more extensive,such as soil,bran,and river sand.These processing methods have been inherited from generation to generation.Nowadays,the commonly used methods are bran-fried,stir-fried,sand-fried,etc.In this paper,by reviewing the relevant literature in China and abroad in recent years,the main active ingredients and relat-ed pharmacological effects of Coicis Semen are sorted out,and the effects of different origins and processing methods on the chemical composition of Coicis Semen are summarized,with a view to providing references for the comprehensive development and utilization of Coicis Semen and the further study of its mechanism of action.

Coicis Semenactive ingredientsdifferent originsprocessingpharmacological effects

吴静雨、陈晓凡、徐万爱、陈雨迅、于欢

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江西中医药大学 药学院, 江西 南昌 330004

薏苡仁 活性成分 不同产地 炮制 药理作用

2023年全国中药特色技术传承人才培训项目江西省中医药中青年骨干人才(第四批)项目国家中医药管理局第二届全国名中医(龚千锋)传承工作室项目国家中医药管理局2022年全国名老中医药专家(龚千锋)传承工作室建设项目江西省中医药管理局第二届国医名师(龚千锋)工作室项目

国中医药人教函[2023]96号赣中医药科教字[2022]7号国中医药办人教函[2022]245号国中医药人教函[2022]75号赣中医药综合[2021]12号

2024

中国中药杂志
中国药学会

中国中药杂志

CSTPCD北大核心
影响因子:1.718
ISSN:1001-5302
年,卷(期):2024.49(6)
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