首页|胆木化学成分、药理作用研究进展及质量标志物的预测分析

胆木化学成分、药理作用研究进展及质量标志物的预测分析

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胆木是一种药用价值较高的中药材,含有生物碱类、五环三萜及其皂苷类、有机酚酸及其苷类、环烯醚萜类、黄酮类等多种类型化学成分,具有抗病毒、抗菌、解热镇痛、抗炎、免疫调节等作用。该文对胆木已报道的化学成分和药理作用进行系统性综述,并根据质量标志物的概念,从植物亲缘性、化学成分特有性、传统药性药效、化学成分可测性、入血成分及不同产地和采收时期几方面对胆木的质量标志物进行预测分析,以期为胆木的质量评价研究提供依据。
Chemical constituents and pharmacological effects of Nauclea officinalis and predictive analysis of its quality markers
Nauclea officinalis is a Chinese medicinal material with a high medicinal value,which contains various chemical constituents such as alkaloids,pentacyclic triterpenoids and their saponins,organic phenolic acids and their glycosides,iridoids,and flavonoids.It has antiviral,antibacterial,antipyretic,analgesic,anti-inflammatory,and immunoregulatory functions.This article systematically reviewed the reported chemical constituents and pharmacological effects of N.officinalis.According to the concept of quality markers,the quality markers of N.officinalis were predicted and analyzed from the aspects of plant kinship,specificity of chemical constituents,traditional drug efficacy,measurability of chemical constituents,plasma components,and different producing areas and harvest times,in order to provide a basis for the quality evaluation of N.officinalis.

Nauclea officinalischemical constituentspharmacological effectquality marker

裴晓婷、彭雷、曾纪锴、陈卫东

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安徽中医药大学药学院,安徽合肥 230012

长三角药物高等研究院,江苏南通 226133

合荣嘉医药科技(南通)有限公司,江苏南通 226133

海南森祺制药有限公司,海南海口 570100

省部共建安徽道地中药材品质提升协同创新中心,安徽合肥 230012

中药资源保护与开发研究所,安徽合肥 230012

中药复方安徽省重点实验室,安徽合肥 230012

中药饮片制造新技术安徽省重点实验室,安徽合肥 230012

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胆木 化学成分 药理作用 质量标志物

国家中医药局高水平中医药重点学科建设项目海南省财政科技计划

ZDKJ201805

2024

中国中药杂志
中国药学会

中国中药杂志

CSTPCD北大核心
影响因子:1.718
ISSN:1001-5302
年,卷(期):2024.49(8)
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