大柴胡汤历史沿革、临床应用和药理作用研究进展及其质量标志物预测分析
Progress on historical evolution,clinical application,and pharmacological effects of Dachaihu Decoction and predictive analysis of its quality markers
汲晓玲 1周游 1李泽浩 1强发晶 2邴一凡 1赵俊毅 2邹翔 2曲中原1
作者信息
- 1. 哈尔滨商业大学药学院,黑龙江哈尔滨 150076
- 2. 哈尔滨商业大学药物工程技术研究中心,黑龙江哈尔滨 150076
- 折叠
摘要
大柴胡汤是和解少阳、内泻热结之经典方剂,张仲景专为少阳、阳明合病所设.国内外大量研究表明大柴胡汤具有保肝、利胆、抗炎等药理作用,现代临床多用于治疗急性胰腺炎、急性胆囊炎、胆石症等消化系统疾病.该研究采用文献计量学与统计学相结合的方法,选择古籍数据库及中国知网(CNKI)数据库,检索大柴胡汤的相关文献,考证该方组成与剂量、炮制方法、主治病症及现代临床应用,并以质量标志物(Q-marker)的"五原则"为纲领预测大柴胡汤的质量标志物.结果提示柴胡皂苷a、黄芩苷和6-姜辣素等可作为大柴胡汤潜在的质量标志物,为中医临床研究及复方制剂开发和应用提供依据.
Abstract
Dachaihu Decoction is a classic prescription with the function of harmonizing Shaoyang and purging away internal stasis of heat,which was specially developed by Master ZHANG Zhongjing for the concurrent disease of Shaoyang and Yangming.A large number of international studies have shown that Dachaihu Decoction has liver protection,gallbladder benefit,anti-inflammatory,and other pharmacological effects and is mostly used in modern clinical treatment of acute pancreatitis,acute cholecystitis,cholelithiasis,and other digestive diseases.This paper combined bibliography and statistics and selected the ancient book database and CNKI database to search the relevant literature on Dachaihu decoction,verify the composition and dosage,processing method,main diseases,and modern clinical application,and predict its quality markers(Q-markers)based on the"five principles"of Q-markers.The results suggest that saikosaponin a,baicalin,and 6-gingerol can be selected as potential Q-markers for Dachaihu Decoction,so as to provide a basis for the clinical research of traditional Chinese medicine and the development and application of compound preparations.
关键词
大柴胡汤/历史沿革/临床应用/药理作用/质量标志物Key words
Dachaihu Decoction/historical evolution/clinical application/pharmacological effect/quality marker引用本文复制引用
基金项目
黑龙江省中医药局中医药经典普及化专项(ZYW2022-063)
黑龙江省重点研发计划指导类项目(GZ20210110)
黑龙江省自然科学基金(LH2022H001)
哈尔滨商业大学产业化项目支持计划(22CZ07)
出版年
2024
NETL
NSTL
万方数据