首页|莱菔子生熟异治的研究进展及质量标志物预测分析

莱菔子生熟异治的研究进展及质量标志物预测分析

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莱菔子为重要的药食兼用的传统中药，是"生熟异治，生升熟降"的典型药物。该文以莱菔子生熟异治为主题，就近年来生、熟莱菔子的化学成分和药理作用等各方面的差异研究进行综述，较全面、系统地总结了莱菔子生熟异治的研究，并基于中药质量标志物(Q-marker)的原则，通过对生、熟莱菔子的化学成分生源途径、化学成分检测技术以及双向调节药效与化学成分关联的比较分析，发现莱菔素和萝卜硫苷可分别作为生、熟莱菔子质量标志物的候选化合物。以期为莱菔子的深入炮制研究、新药开发及其临床应用安全性和有效性的提高提供参考。
Research progress in raw and processed Raphani Semen and prediction of quality markers
Raphani Semen,with both edible and medicinal values,is a typical Chinese herbal medicine with different effects before and after processing.The raw helps ascending and the cooked helps descending.This paper comprehensively summarizes the differences in chemical constituents and pharmacological effects between raw and processed Raphani Semen that are reported in recent years.Based on the principle of quality markers(Q-markers)of traditional Chinese medicines,the chemical constituent sources,chemical constituent detection techniques,and correlation between bidirectional regulatory efficacy and chemical constituents are compared between raw and processed Raphani Semen.The results suggest that sulforaphene and glucoraphanin could be used as candidate Q-markers of raw and processed Raphani Semen,respectively.This review is expected to provide a reference for further research on the processing,new drug development,and improvement of safety and effectiveness of Raphani Semen in clinical application.

Raphani Semenmedicinal materials treating different diseases before and after processingchemical constituentspharmacological effectsactive ingredientquality markers

梁佩云、黄钰景、陈浩铭、曹昊恒、吴银冰、陈婷婷、陈宜、范红霞、郑俊霞

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广东工业大学生物医药学院,广东广州 510006

莱菔子 生熟异治 化学成分 药理作用 活性成分 质量标志物

国家自然科学基金面上项目广东省自然科学基金面上项目

820739772023A1515011445

2024

10.19540/j.cnki.cjcmm.20231219.201

中国中药杂志
中国药学会

中国中药杂志

CSTPCD北大核心
影响因子：1.718
ISSN：1001-5302
年,卷(期)：2024.49(8)
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