慢性心力衰竭(chronic heart failure，CHF)是一种严重的心血管疾病，其发病机制极为复杂，包括心肌结构和功能异常、炎症反应的激活等多种因素。NOD样受体热蛋白结构域相关蛋白3(NOD-like receptor thermal protein domain associated protein 3，NLRP3)炎症小体作为炎症细胞传感器，在CHF的发生和发展中发挥着关键作用。研究表明，NLRP3炎症小体的活化可以诱导炎症反应，导致心脏炎症，损害心肌功能，并与CHF的严重程度相关联。中医药作为一种传统的治疗方式，近年来受到了越来越多的关注。中医药的药物和治疗方法在抑制炎症反应、减轻心肌细胞焦亡、改善心肌结构和功能、抑制心肌纤维化能等方面显示出潜在的疗效。中医药中的多种药物及其提取物已经被用于CHF的治疗，其机制可能涉及到NLRP3炎症小体的抑制以及炎症反应的减轻。该文综述了 NLRP3炎症小体的组成、结构特点、启动与激活方式及其在CHF中的作用机制，同时探讨了中医药干预NLRP3炎症小体防治CHF的研究进展，旨在更深入了解CHF发病机制，为未来开发新的治疗策略提供参考和依据。
Mechanisms of NLRP3 inflammasome-mediated pyroptosis in chronic heart failure and research progress in traditional Chinese medicine
Chronic heart failure(CHF)is a severe cardiovascular disease characterized by a complex pathogenesis involving myocardial structural and functional abnormalities and the activation of inflammatory responses.The NOD-like receptor thermal protein domain-associated protein 3(NLRP3)inflammasome,acting as a sensor for inflammatory cells,plays a pivotal role in the development of CHF.Research indicates that the activation of the NLRP3 inflammasome can induce inflammatory responses,leading to cardiac inflammation and impairing myocardial function,and it is correlated with the severity of CHF.Traditional Chinese medicine(TCM)has garnered increasing attention as a traditional therapeutic approach in recent years.Various TCM drugs and treatment methods have exhibited potential efficacy in suppressing inflammatory responses,alleviating myocardial cell pyroptosis,improving myocardial structure and function,and inhibiting myocardial fibrosis.Several TCM drugs and their extracts have been utilized in CHF treatment,with mechanisms potentially involving the inhibition of NLRP3 inflammasomes and the mitigation of inflammatory responses.The article provided an overview of the composition,structural characteristics,initiation,and activation modes of the NLRP3 inflammasome,its mechanisms in CHF,and the research progress of TCM in CHF treatment.It aims to offer references and foundations for a deeper understanding of CHF pathogenesis and subsequent development of new therapeutic strategies.
traditional Chinese medicinechronic heart failureNLRP3pyroptosis
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NSTL
万方数据
