诱导肝星状细胞铁死亡在肝纤维化防治中的研究进展
Research progress on induced hepatic stellate cell ferroptosis in prevention and treatment of liver fibrosis
牛媛媛 1樊泽坤 1汪龙德 2李正菊 1杜晓娟 1胥文娟 3郭林静1
作者信息
- 1. 甘肃中医药大学,甘肃 兰州 730000
- 2. 甘肃中医药大学附属医院,甘肃 兰州 730020
- 3. 甘肃省中医院,甘肃 兰州 730050
- 折叠
摘要
肝纤维化是慢性肝病进展的关键病理阶段,若本病失治误治,则可进一步恶化为肝衰竭事件,严重影响患者生活质量,并伴随沉重医疗成本消耗.肝星状细胞(hepatic stellate cell,HSC)活化引发细胞外基质(extracellular matrix,ECM)沉积是肝纤维化的重要驱动因素,而铁死亡是活化HSC清除或逆转为失活表型的有效策略,因此通过调节铁死亡来抑制HSC的激活与增殖是治疗本病的关键,进一步衍生出诱导HSC铁死亡(包括RNA结合蛋白、非编码RNA、化学制品、中药活性组分)以干预肝纤维化的前景方向.基于此,该文以活化HSC引发ECM沉积为切入点,重点梳理总结诱导HSC铁死亡在延缓肝纤维化进程中的作用机制,以期能不断丰富肝纤维化的临床实践,并为下一步的基础研究提供参考依据.
Abstract
Liver fibrosis is a key pathological stage in the progression of chronic liver disease.If the disease is mistreated,it can further deteriorate into liver failure,which seriously affects the quality of life of patients and brings heavy medical costs.Hepatic stel-late cell(HSC)activation triggers extracellular matrix(ECM)deposition,which plays an important driving role in liver fibrosis,and ferroptosis is an effective strategy to clear or reverse the activation of HSCs into a deactivated phenotype.Therefore,inhibiting the acti-vation and proliferation of HSCs by regulating ferroptosis is the key to the treatment of this disease,so as to derive the prospect of indu-cing ferroptosis of HSCs(including RNA-binding proteins,non-coding RNA,chemicals,and active components of traditional Chinese medicine)to intervene in liver fibrosis.On this basis,this paper started from the activation of HSCs to induce ECM deposition and fo-cused on summarizing the mechanism of inducing HSC ferroptosis in delaying the progression of liver fibrosis,so as to continuously en-rich the clinical practice of liver fibrosis and provide a reference for subsequent basic research.
关键词
肝纤维化/HSC活化/ECM沉积/铁死亡/中药活性组分/非编码RNAKey words
liver fibrosis/HSC activation/ECM deposition/ferroptosis/active components of traditional Chinese medicine/non-coding RNA引用本文复制引用
基金项目
国家自然科学基金(82160883)
甘肃省自然科学基金(23JRRA1579)
兰州市科技计划(2022-3-26)
甘肃省教育厅优秀研究生"创新之星"项目(2023CXZX-731)
甘肃中医药大学科学研究与创新基金(2022KCYB-6)
出版年
2024
NETL
NSTL
万方数据