Ligustilide is the main active component of the volatile oil from Angelica sinensis and Ligusticum chuanxiong in the Um-belliferae family.It is a phthalein compound with anti-inflammatory,analgesic,antioxidant,anti-tumor,anti-atherosclerosis,neuro-protective,and other pharmacological effects.It can improve the permeability of the blood-brain barrier and has important potential in the treatment of neurodegenerative diseases and other nervous system diseases,such as Alzheimer's disease,ischemic stroke,Parkin-son's disease,vascular dementia,and depression.Therefore,the mechanism of ligustilide in the treatment of nervous system diseases was summarized to provide a reference for drug development and clinical application.
ligustilidenervous system diseaseneurodegenerative diseasesAlzheimer's diseaseischemic strokeParkinson's diseasevascular dementia
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