首页|多源信息融合的中药制造白术饮片多维质量属性一致性的诊断策略

多源信息融合的中药制造白术饮片多维质量属性一致性的诊断策略

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中药饮片的质量控制是中药产业的关键任务之一。该研究基于多源信息融合技术,收集近红外光谱、电子舌感官等信息,建立白术饮片的整体质量一致性评价方法,为白术饮片的整体质量评价提供方法支撑。以 23 批不同来源的白术样品为研究载体,分别测定静止和运动状态下的近红外光谱信息,电子舌感官信息、水分及浸出物含量,采用多源信息融合技术评价白术饮片的整体质量。结果表明,批号 16122103、801000509、801000352、701003656、HX21L01、160956 为静止状态白术粉末的差异批次,批号 701003298、16122103、701003656、701003107、801000229、18090404 为运动状态的白术饮片的差异批次,含水量无差异批次,批号 801000509 为浸出物含量差异批次,批号 150721004、151237、160703004、HX21M01、HX21K04、HX21K01、601003516 为电子舌感官信号差异批次。进一步,采用数据层融合对白术饮片进行整体性分析,共发现批号 150721004、HX21M01、HX21K04、HX21K01 的样本超过 95%控制限,与其他样品整体质量存在差异。该研究综合运用水分、近红外光谱等信息,成功对 23 批次的白术饮片进行差异批次的诊断,实现了质量一致性评价,为中药饮片质量一致性评价提供借鉴。
Consistency evaluation of multidimensional quality attributes of Atractylodis Macrocephalae Rhizoma by fusion of multi-source information
The quality control of Chinese medicinal decoction pieces is one of the key tasks in the traditional Chinese medicine industry.In this study,multi-source information fusion was employed to fuse the data from near-infrared spectroscopy,electronic tongues,and other tests and establish an overall quality consistency evaluation method for Atractylodis Macrocephalae Rhizoma,which provided methodological support for the overall quality evaluation of Atractylodis Macrocephalae Rhizoma.The near-infrared spectroscopy information was measured in both static and dynamic states for 23 batches of Atractylodis Macrocephalae Rhizoma samples from different sources,and the electronic tongue sensory information,moisture content,and leachate content were measured.The overall quality of Atractylodis Macrocephalae Rhizoma was evaluated by multi-source information fusion.The results showed that the near-infrared spectroscopy information of 16122103,801000509,801000352,701003656,HX21L01,and 160956 was different from that of other batches of Atractylodis Macrocephalae Rhizoma powder in the static state,and 701003298,16122103,701003656,701003107,801000229,and 18090404 were the different batches in the dynamic state.The moisture content showed no significant difference between batches.The leachate content in the batch 801000509 was different from that in other batches.The electronic tongue sensory information of 150721004,151237,160703004,HX21M01,HX21K04,HX21K01,and 601003516 was different from that of other batches.Furthermore,data layer fusion was employed to analyze the overall quality of Atractylodis Macrocephalae Rhizoma.Four batches,150721004,HX21M01,HX21K04,and HX21K01,showed the parameters exceeding the 95%control limits and differed from the other samples in terms of the overall quality.This study integrated the information of moisture,near-infrared spectroscopy,and other sources to evaluate the quality consistency among 23 batches of Atractylodis Macrocephalae Rhizoma samples,which provides a reference for the quality consistency evaluation of Chinese medicinal decoction pieces.

traditional Chinese medicine productionmulti-source informationnear-infraredAtractylodis Macrocephalae Rhizo-maconsistency evaluation

韩燕雨、吴志生、戴平、王恺怡、赵静、张晓梦、王晓萌、王静、郇星月、郭新雨、李楠、姚璐、王淑英、王逸飞

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北京中医药大学 中药学院,北京 102488

中药制药与新药开发教育部工程研究中心,北京 102488

福建中医药大学 药学院,福建 福州 350122

北京同仁堂股份有限公司,北京 100031

北京中医药大学 房山医院,北京 102499

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中药制造 多源信息 近红外 白术 一致性评价

国家重点研发计划国家重点研发计划国家自然科学基金江西省重大科技研发专项国家医学攻关产教融合创新平台中药智能制造工程平台项目

2023YFC35045052022YFC35019028227411020203ABC28W01890010062820031

2024

中国中药杂志
中国药学会

中国中药杂志

CSTPCD北大核心
影响因子:1.718
ISSN:1001-5302
年,卷(期):2024.49(9)
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