该研究旨在应用知识图谱技术对雄黄研究现状和热点进行分析，为雄黄临床应用和未来深入研究提供指导。检索中国知网(CNKI)、万方(Wanfang)、维普(VIP)、中国生物医学文献服务系统(SinoMed)、Web of Science等5个数据库雄黄研究相关中、英文文献，利用NoteExpress文献管理软件对文献进行筛选，利用CiteSpace软件对作者、机构、关键词等进行可视化分析与展示。共纳入雄黄研究相关中文文献2879篇，英文文献194篇;《中国中药杂志》《Journal of Ethnopharmacology》分别是发文量最多的中、英文期刊;雄黄在皮肤病、血液病、癌症治疗中应用广泛;姜泓团队中、英文文献发文量均为最高;中国医科大学公共卫生学院、中国中医科学院分别是中、英文文献发文量最多的机构;雄黄研究主要集中在临床应用、作用机制、减毒增效等方面。雄黄研究的作者和机构主要集中在国内，其治疗血液病与癌症机制、雄黄减毒增效是现阶段研究热点，雄黄"异病同治"作用机制需要深入挖掘，亟需开展对雄黄多学科的交叉研究。该研究可为雄黄临床应用提供参考，为深入研究提供思路。
Research hotspots and frontiers of Realgar based on CiteSpace knowledge graph analysis
This study employed knowledge graph technology to analyze the research status and hot spots of Realgar and provide guidance for clinical application and further research of this drug.The research articles both in English and Chinese involving Realgar were retrieved from five databases including CNKI,Wanfang,VIP,SinoMed,and Web of Science.And NoteExpress,a literature management software was used to screen literature.CiteSpace was utilized for visualized analysis and presentations of the authors,insti-tutions,and keywords.2879 articles in Chinese and 194 articles in English were included.China Journal of Chinese Materia Medica and Journal of Ethnopharmacology were the top Chinese and English journals in terms of publication volume.Realgar is widely used in the treatment of skin diseases,blood diseases,and cancer.JIANG Hong was the author who have published more articles in Chinese and English working with teams.School of Public Health of China Medical University and China Academy of Chinese Medical Sciences published the most articles in Chinese and English.The research on Realgar mainly focuses on clinical application,mechanism of ac-tion,reduction of toxicity,and enhancement of efficacy.The authors and institutions of Realgar research are mainly concentrated in China.The study on the mechanism of treating hematological diseases and cancer with Realgar,as well as the research on its effects of reducing toxicity and enhancing efficacy,are the current research hotspots.The mechanism of"same treatment for different diseases"in Realgar needs to be further explored.It is urgent to carry out interdisciplinary research on Realgar.This study can provide a refe-rence for the clinical application of Realgar and provide ideas for further research on Realgar.
RealgarCiteSpaceknowledge graphclinical applicationreducing toxicity and enhancing efficacy
NETL
NSTL
万方数据
