Research progress on curcumin improving chronic low-grade inflammation and related diseases
Chronic low-grade inflammation(CLGI),a relatively new concept without a clear definition,refers to a nonspecific,chronic,continuous,and low-grade inflammation state,and it is closely associated with various chronic diseases,including obesity,inflammatory bowel disease,neurodegenerative diseases,and tumors.Improvement of CLGI can slow down disease progression.Anti-inflammatory treatment is an important strategy for prevention and treatment of CLGI.However,there is currently no definitive drug treatment method.Curcumin is a polyphenolic compound extracted from the rhizome of zingiberaceae,with significant anti-inflammatory activity.Research has shown that curcumin can play an anti-inflammatory role by regulating NF-κB,JAK/STAT,PI3K/Akt,MAPK,NLRP3 inflammasome,Nrf2/ARE,and other inflammation-related pathways.This paper summarized the anti-inflammatory mecha-nisms,pharmacological effect,and clinical application of curcumin in improving CLGI and other diseases,so as to provide a reference for in-depth research and clinical application of curcumin in improving CLGI.
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