摘要
慢性低度炎症(chronic low-grade inflammation,CLGI)属于较新的概念,尚无明确定义,一般认为是一种非特异性、慢性、持续、低度的炎症状态,与肥胖、炎症性肠病、神经退行性疾病、肿瘤等多种慢性疾病密切相关,改善CLGI可有效减缓相关疾病进程.抗炎治疗是防治CLGI的重要策略,但目前还没有确切的药物治疗方法.姜黄素是从姜科植物根茎中提取的多酚类化合物,具有显著的抗炎活性.研究表明,姜黄素通过调节核转录因子-κB(NF-κB)、Janus激酶信号转导/转录激活因子通路(JAK/STAT)、磷脂酰肌醇 3 激酶/蛋白激酶B(PI3K/Akt)、促分裂素原活化蛋白激酶(MAPK)、NOD样受体蛋白 3(NLRP3)炎症小体和核因子E2 相关因子 2/抗氧化反应元件(Nrf2/ARE)等炎症相关通路发挥抗炎作用.该文系统总结了姜黄素的抗炎作用机制及其在改善慢性低度炎症相关疾病中的药理作用和临床应用情况,以期为姜黄素改善CLGI的深入研究和临床应用提供参考.
Abstract
Chronic low-grade inflammation(CLGI),a relatively new concept without a clear definition,refers to a nonspecific,chronic,continuous,and low-grade inflammation state,and it is closely associated with various chronic diseases,including obesity,inflammatory bowel disease,neurodegenerative diseases,and tumors.Improvement of CLGI can slow down disease progression.Anti-inflammatory treatment is an important strategy for prevention and treatment of CLGI.However,there is currently no definitive drug treatment method.Curcumin is a polyphenolic compound extracted from the rhizome of zingiberaceae,with significant anti-inflammatory activity.Research has shown that curcumin can play an anti-inflammatory role by regulating NF-κB,JAK/STAT,PI3K/Akt,MAPK,NLRP3 inflammasome,Nrf2/ARE,and other inflammation-related pathways.This paper summarized the anti-inflammatory mecha-nisms,pharmacological effect,and clinical application of curcumin in improving CLGI and other diseases,so as to provide a reference for in-depth research and clinical application of curcumin in improving CLGI.
基金项目
四川省中医药科技产业创新团队专项(2022C009)
四川省科技服务业平台资金项目(A-2022N-51)
四川省科技厅基本科研业务专项(2022JDKY0036)
NETL
NSTL
万方数据