基于铁死亡探讨慢性肾脏病的发病机制及中医药干预进展
Pathogenesis of ferroptosis on chronic kidney disease and traditional Chinese medicine intervention:a review
杨璧英 1刘相 1胡爽 1彭亚军 1张伟宁 1刘丙龙 1何泽云1
作者信息
- 1. 湖南中医药大学 第一附属医院,湖南 长沙 410021
- 折叠
摘要
慢性肾脏病(chronic kidney disease,CKD)起病隐匿,因其发病率高、知晓率低、诊断率低、预后差和医疗费用高等特点,已成为危害人类健康的重要公共卫生问题.目前已有多项研究表明CKD在其发生发展过程中会出现不同程度的铁死亡特征,而中药可以通过靶向铁代谢、脂质过氧化及抗氧化系统等抑制铁死亡来延缓CKD的进展,铁死亡干预机制逐渐成为CKD研究的重点领域之一.中医药宝库集数千年传统中医经验与智慧于一身,注重人体功能的整体调节,能够激发人体的抗病和康复能力,对治疗CKD具有一定优势,但目前尚缺乏中医药干预铁死亡治疗CKD及铁死亡与CKD发病机制的总结性综述.该文汇总国内外最新研究进展,简述铁死亡主要的作用机制,对铁死亡与CKD发病机制的最新研究进展进行了系统综述,融合了与CKD铁死亡相关的"虚""瘀""痰浊""毒"等中医理论,总结了中药活性成分、中药复方干预铁死亡治疗CKD的研究现状,以期从铁死亡角度为中医药防治CKD提供新靶点和新方向.
Abstract
Chronic kidney disease(CKD)is an insidious disease that has become a significant global public health issue due to its high incidence rate,low awareness,low diagnostic rate,poor prognosis,and high medical costs.Recent studies have shown that CKD development is associated with varying degrees of ferroptosis features.Traditional Chinese medicine(TCM)can regulate iron metabolism,lipid peroxidation,antioxidant systems to inhibit ferroptosis and delay the progression of CKD.Consequently,the intervention mechanism of ferroptosis has become one of the focuses of CKD research.TCM has thousands of years of traditional experience and wisdom.It focuses on the overall regulation of human body functions and can stimulate the body's disease resistance and recovery capabilities,which has certain advantages in treating CKD.However,there is currently a lack of comprehensive articles on the application of TCM in intervening ferroptosis to treat CKD and the pathogenesis of ferroptosis in CKD.Therefore,this article summarizes the latest research progress both domestically and internationally,briefly introduces the main mechanisms of ferroptosis,and systematically reviews the relationship between ferroptosis and CKD.The article integrates TCM theories related to ferroptosis in CKD,including"deficiency""stasis""phlegm turbidity"and"toxins"and summarizes the research status of active ingredients and herbal formulas in intervening ferroptosis to treat CKD.By considering ferroptosis from a new perspective,this article aims to provide new targets and directions for the application of TCM in treating CKD.
关键词
铁死亡/慢性肾脏病/铁代谢/脂质过氧化/抗氧化系统/中药活性成分/中药复方Key words
ferroptosis/chronic kidney disease/iron metabolism/lipid peroxidation/antioxidant system/active ingredients in tra-ditional Chinese medicine/Chinese herbal formulas引用本文复制引用
基金项目
湖南省卫生健康委卫生科研课题(W20243266)
湖南省自然科学基金(2023JJ30473)
湖南省自然科学基金面上项目(2021JJ30522)
湖南省中医重点专科建设项目(czxmsbk-2023001)
刘良院士工作站湖南省中西医结合肾病研究中心项目()
出版年
2024
NETL
NSTL
万方数据