藏族药小叶莲化学成分和药理作用研究进展
Research progress on bioactive constituents and pharmacological effects of Tibetan medicine Sinopodophylli Fructus
徐名慧 1仇文婷 2晋玲 3栗孟飞 4佟海英5
作者信息
- 1. 甘肃农业大学 农学院 干旱生境作物学国家重点实验室,甘肃 兰州 730070;包头医学院 药学院,内蒙古 包头 014040
- 2. 甘肃省甘南藏族自治州农业科学研究所,甘肃 合作 747000
- 3. 甘肃中医药大学 西北中藏药省部共建协同创新中心,甘肃 兰州 730000
- 4. 甘肃农业大学 农学院 干旱生境作物学国家重点实验室,甘肃 兰州 730070
- 5. 北京中医药大学 中医学院,北京 100029
- 折叠
摘要
小叶莲Sinopodophylli Fructus是藏族习用药材,具有调经活血功效.目前从小叶莲中分离鉴定的化学成分主要有木脂素类(15 种,如鬼臼毒素、去氧鬼臼毒素、4'-去甲鬼臼毒素等)和黄酮类(20 种,如槲皮素、山柰酚、芦丁等),具有抗肿瘤、抑菌、降血脂等药理作用;另外,还含有蛋白质、脂肪酸、多糖、维生素、氨基酸、微量元素等其他成分.该文根据国内外文献报道,总结并综述了小叶莲中化学成分和药理作用方面的研究进展,以期为小叶莲资源的开发及临床合理应用提供参考.
Abstract
Sinopodophylli Fructus is a traditional medicine used by the Tibetan people.It is known for its ability to regulate men-struation and promote blood circulation.Presently,bioactive constituents that have been isolated and identified from Sinopodophylli Fructus mainly include 15 lignans(e.g.,podophyllotoxin,deoxypodophyllotoxin,and 4'-demethylpodophyllotoxin)and 20 flavonoids(e.g.,quercetin,kaempferol,and rutin).These components exhibit pharmacological effects such as anticancer,antibacterial,and lipid-lowering activities.Additionally,Sinopodophylli Fructus contains other components such as proteins,fatty acids,polysaccha-rides,vitamins,amino acids,and trace elements.According to the relevant literature reports in China and abroad,this article re-viewed the chemical constituents and pharmacological effects of Sinopodophylli Fructus,aiming to provide references for the develop-ment and rational clinical application of this medicinal resource.
关键词
小叶莲/木脂素/黄酮/抗肿瘤/抑菌/辅助药理作用Key words
Sinopodophylli Fructus/lignans/flavonoids/anticancer/antibacterial/auxiliary pharmacological effect引用本文复制引用
基金项目
国家自然科学基金(81560617)
国家中医药局道地药材生态种植与质量保障项目(202103003)
出版年
2024
NETL
NSTL
万方数据