中药及活性成分靶向M1/M2巨噬细胞极化平衡干预肥胖合并2型糖尿病的研究进展
Research progress of traditional Chinese medicines and active ingredients targeting M1/M2 macrophage polarization balance in intervening obese with type 2 diabetes
李纪新 1邱林杰 1任燕 1王文茹 1杨振宇 2李美洁 1栗文婕 1张晋1
作者信息
- 1. 中国中医科学院西苑医院,北京 100091
- 2. 黑龙江中医药大学,黑龙江哈尔滨 150040
- 折叠
摘要
2型糖尿病(type 2 diabetes,T2DM)是以葡萄糖毒性、脂肪毒性、胰岛素抵抗等病理表现为主要特征的代谢紊乱疾病,是亟待解决的全球性健康问题.肥胖是T2DM发生发展的关键危险因素,肥胖合并T2DM增加了胰岛素抵抗和代谢异常程度.研究发现,脂肪与胰岛组织炎症微环境平衡的打破,是T2DM发生发展的重要原因.巨噬细胞是脂肪和胰岛组织免疫稳态及炎症反应的主要参与者,肥胖合并T2DM个体存在M1/M2巨噬细胞极化平衡紊乱,推动了糖脂代谢异常的进展.因此,恢复巨噬细胞极化的平衡,是治疗肥胖合并T2DM的重要途径.相关科研人员已证明中医药疗法可调控巨噬细胞极化实现对肥胖合并T2DM的治疗.因此,该研究基于现有证据,系统综述中医药靶向M1/M2巨噬细胞极化平衡改善肥胖合并T2DM的研究进展,以期为肥胖合并T2DM的中医药临床诊治及生物学基础的探索提供证据支持.
Abstract
Type 2 diabetes(T2DM)is a metabolic disorder marked by glucose toxicity,lipotoxicity,insulin resistance,and other pathological manifestations,representing a pressing global health concern.Obesity stands out as a pivotal risk factor for T2DM development.When combined with T2DM,obesity exacerbates insulin resistance and metabolic abnormalities.The disturbance in the inflammatory microenvironmental balance between adipose and pancreatic islet tissue emerges as a significant contributor to obese with T2DM development.Macrophages play a crucial role in maintaining immune homeostasis and responding to inflammation in adipose and pancreatic islet tissue.Individuals with obese with T2DM exhibit an imbalanced M1/M2 macrophage polarization,contributing to the progression of glycolipid metabolism abnormalities.Hence,restoring the equilibrium of macrophage polarization becomes imperative for obese with T2DM treatment.Scientific researchers have demonstrated that traditional Chinese medicine(TCM)therapies can effectively modulate macrophage polarization,offering a viable approach for treating obese with T2DM.In light of the existing evidence,this study systematically reviewed the research progress of TCM targeting the balance of M1/M2 macrophage polarization to ameliorate obese with T2DM,so as to furnish evidence supporting the clinical diagnosis and treatment of obese with T2DM with TCM while also contributing to the exploration of the biological basis of obese with T2DM.
关键词
肥胖/2型糖尿病/巨噬细胞极化/中医药/活性成分Key words
obesity/type 2 diabetes/macrophage polarization/traditional Chinese medicine/active ingredients引用本文复制引用
基金项目
中国中医科学院科技创新工程项目(CI2021A03005)
出版年
2024
NETL
NSTL
万方数据