香豆素类化合物的生物合成关键酶及活性研究进展
Research progress in biosynthesis-related enzymes of coumarin compounds and their bioactivities
吕华伟 1梁慧敏 1朱梦迪 2王鸿 1李行诺1
作者信息
- 1. 浙江工业大学药学院,浙江省中药大健康产品创新研发与数智化制造中医药重点实验室,浙江湖州 313000
- 2. 浙江工业大学分析测试中心,浙江杭州 310014
- 折叠
摘要
香豆素是一类以苯骈α-吡喃环为母核的天然产物,许多香豆素衍生物具有多种药理活性,如抗菌、抗炎、抗肿瘤、抗凝血、抗骨质疏松、杀虫等,在医药、农业领域发挥了重要作用.香豆素衍生物的开发利用一直备受关注.随着基因测序技术的成熟以及合成生物学的快速发展,香豆素衍生物的生物合成研究已取得许多重要进展,也日益受到国内外学者的关注.该文综述了目前已报道的香豆素衍生物的生物合成关键酶,如细胞色素P450酶(cytochrome P450 enzyme,CYP450)、异戊烯基转移酶(prenyltransferase,PT)、UDP-葡萄糖基转移酶(UDP-glucosyltransferase,UGT)等,并对其在抗肿瘤、抗炎、抗氧化、抗菌等方面的药理活性进行系统总结,期望为香豆素衍生物的生物合成研究及其药用潜力的进一步挖掘提供参考价值.
Abstract
Coumarins are natural products with benzopyran ring as the parent nucleus.Numerous coumarin derivatives exhibit a va-riety of pharmacological activities,including antibacterial,anti-inflammatory,antitumor,anti-coagulant,anti-osteoporotic,and insecti-cidal activities.Therefore,they play an important role in both medicine and agriculture.The development and utilization of coumarin derivatives have attracted increasing attention.The advancement of gene sequencing technology and the rapid progress in synthetic bio-logy have led to significant advancement in the biosynthesis of coumarin derivatives,and has received increasing attention from global researchers.This paper presents a comprehensive overview of the key biosynthesis-related enzymes of coumarin derivatives,such as cy-tochrome P450 enzyme(CYP450),prenyltransferase(PT),UDP-glucosyltransferase(UGT).Additionally,the pharmacological ac-tivities of these enzymes,including anti-tumor,anti-inflammatory,antioxidant,and antibacterial activities,are systematically summa-rized.This review aims to provide a valuable reference for the biosynthesis of coumarin derivatives and further exploration of their me-dicinal potential.
关键词
香豆素/细胞色素P450酶/异戊烯基转移酶/葡萄糖基转移酶/生物活性Key words
coumarin/cytochrome P450 enzyme/prenyltransferase/glucosyltransferase/bioactivity引用本文复制引用
基金项目
国家重点研发计划项目(2022YFC2804204)
浙江省基础公益研究计划项目(ZCLTGC24H2801)
出版年
2024
NETL
NSTL
万方数据