中医药防治血管钙化的研究进展
Research progress in prevention and treatment of vascular calcification with traditional Chinese medicine
杨惠茹 1宋珊杉 1易小莉 1余军 2许传铭1
作者信息
- 1. 江西中医药大学医学转化中心,江西南昌 330004
- 2. 天普大学Lewis Katz医学院,美国费城19140
- 折叠
摘要
血管钙化是一个病变阶段,参与心血管疾病的发生发展过程,严重威胁着人类的生命健康安全,但目前临床上能够完全逆转或治愈血管钙化的药物屈指可数.血管钙化的发病机制主要涉及钙磷稳态失衡、细胞自噬障碍、内源性钙抑制丧失及内质网应激引起的细胞凋亡、炎症风暴、细胞成骨转分化和基质囊泡的释放.围绕"温经通脉,活血化瘀"和"补肾健脾,祛湿化浊"的治疗理念,大量中药单体/提取物及中药复方/中成药对血管钙化显示出很好的改善作用,但是它们的具体作用机制尚不明确,有待进一步的研究探索.该文系统地概括了血管钙化的发病机制,并总结了中药防治血管钙化的最新研究进展情况,为中药防治血管钙化的临床应用提供理论支持.
Abstract
Vascular calcification is a pathological stage involved in the occurrence and development of cardiovascular diseases,seriously threatening human life and health.At present,few drugs can completely reverse or cure vascular calcification in clinical practice.The pathogenesis of vascular calcification mainly involves the disturbance of calcium and phosphorus homeostasis,autophagy dysfunction,loss of endogenous calcium inhibition,and the apoptosis,cytokine storm,cell osteoblastic transdifferentiation,and stromal vesicle release induced by endoplasmic reticulum stress.Following the therapeutic concepts of warming channels and dredging vessels,activating blood and resolving stasis,tonifying kidney and invigorating spleen,and removing dampness and eliminating turbid,a large number of traditional Chinese medicine(TCM)active compounds/extracts and TCM prescriptions/Chinese patent medicines have shown satisfactory performance in treating vascular calcification,while the specific mechanisms remain unclear and awaits further investigations.This article systematically summarized the pathogenesis of vascular calcification and the latest research progress of TCM in the prevention and treatment of vascular calcification,providing theoretical support for the clinical application of TCM in the prevention and treatment of vascular calcification.
关键词
血管钙化/中药/钙磷稳态/成骨转分化/内质网应激/细胞自噬/细胞凋亡Key words
vascular calcification/traditional Chinese medicine/calcium and phosphorus homeostasis/osteogenic transdifferentia-tion/endoplasmic reticulum stress/autophagy/apoptosis引用本文复制引用
基金项目
国家自然科学基金(82160051)
国家自然科学基金(32100908)
江西省"双千计划"项目(jxsq2020101074)
江西省自然科学基金(20232BAB206018)
江西省教育厅科技项目(GJJ2200904)
江西中医药大学中西医结合一级学科(江西省双一流学科)项目(zxyylxk20220103)
出版年
2024
NETL
NSTL
万方数据