Pharmacoeconomic evaluation of Shaoma Zhijing Granules in treatment of tic disorders in children
This study conducted a pharmacoeconomic evaluation of Shaoma Zhijing Granules in the treatment of tic disorder(TD)in children.Firstly,from the perspective of the healthcare system,cost-effectiveness analysis was used to evaluate the economic efficiency of Shaoma Zhijing Granules compared with Changma Xifeng Tablets and Jiuwei Xifeng Granules in the treatment of TD in children.Then,through network Meta-analysis,the overall effectiveness of different regimens was calculated,combined with the total cost of the regimens,to calculate the incremental cost-effectiveness ratio(ICER).Finally,sensitivity analysis was performed to verify the stability of the study results and the credibility of the conclusions.This study included 17 articles,including 9 articles on Chinese patent medicines(3 on Shaoma Zhijing Granules,2 on Jiuwei Xifeng Granules,and 4 on Changma Xifeng Tablets),for the treatment of TD in children,and 8 articles on Chinese patent medicines combined with conventional western medicines(3 on Shaoma Zhijing Granules,2 on Jiuwei Xifeng Granules,and 3 on Changma Xifeng Tablets).In the Chinese patent medicine group,the total cost of Shaoma Zhijing Granules for treating TD was CNY 4 410.00,with clinical total effective rate of 77.53％;the total cost of Jiuwei Xifeng Granules for treating TD was CNY 5 192.70,with clinical total effective rate of 82.13％.The ICER of Jiuwei Xifeng Granules vs Shaoma Zhijing Granules was 169.95,higher than the willingness-to-pay(WTP,cost of increasing efficiency by 1％is CNY 85.70).Therefore,Jiuwei Xifeng Granules did not have a cost-effectiveness advantage over Shaoma Zhijing Granules.The total cost of Changma Xifeng Tablets for treating TD was CNY 1 282.50,with clinical total effective rate of 80.60％.The total cost of Changma Xifeng Tablets was lower and clinical total effective rate was higher than that of Shaoma Zhijing Granules.Overall,Shaoma Zhijing Granules did not have a cost-effectiveness advantage.In the Chinese patent medicine combined with conventional western medicine group,the total cost of Shaoma Zhijing Granules for treating TD+conventional western medicines was CNY 6 768.52/6 778.48,with clinical total effective rate of 96.18％.The total cost of Jiuwei Xifeng Granules+conventional western medicines for treating TD was CNY 6 522.56,with clinical total effective rate of 88.30％.The ICER of Shaoma Zhijing Granules+conventional western medicines vs Jiuwei Xifeng Granules+conventional western medicines was 31.20,lower than WTP.Therefore,Shaoma Zhijing Granules+conventional western medicines had a cost-effectiveness advantage over Jiuwei Xifeng Granules+conventional western medicines.The total cost of Changma Xifeng Tablets+conventional western medicines for treating TD was CNY 1 706.12,with clinical total effective rate of 95.39％.The ICER of Shaoma Zhijing Granules+conventional western medicines vs Changma Xifeng Tablets+conventional western medicines was 6 334.06,higher than WTP.Therefore,although Shaoma Zhijing Granules+conventional western medicines had higher clinical total effective rate compared with Changma Xifeng Tablets+conventional western medicines,it did not have a cost-effectiveness advantage.Overall,for different medication regimens(Chinese patent medicines monotherapy or in combination with conventional western medicines),Shaoma Zhijing Granules and Jiuwei Xifeng Granules both had a cost-effectiveness advantage,but compared with Changma Xifeng Tablets,neither had a cost-effectiveness advantage.For Chinese patent medicines in combination with conventional western medicines,clinical total effective rate of Shaoma Zhijing Granules in combination with conventional western medicines for the treatment of TD in children was the highest.
Shaoma Zhijing Granulestic disorders in childrenpharmacoeconomic evaluationnetwork Meta-analysissensitivity analysis
NETL
NSTL
万方数据
