摘要
苦味作为动物最重要的生理感觉之一,其识别过程主要由苦味受体介导完成.近年来发现该受体不仅在舌头味蕾细胞上表达,而且在呼吸系统、心血管系统、消化系统、生殖系统和神经系统中均有表达,同时也参与调控多种基本生理过程,现作为治疗各类疾病的重要靶点之一.该文对苦味受体的结构、分类、分布及其信号转导通路与不同疾病的关系、苦味受体激动剂等方面进行综述,以期为苦味受体的科学研究提供依据.
Abstract
Bitterness,as one of the most important physiological sensations in animals,is primarily recognized through the mediation of bitter taste receptors.In recent years,it has been found that these receptors are not only expressed in taste bud cells on the tongue but also in the respiratory,cardiovascular,digestive,reproductive,and nervous systems.They are involved in regulating various fundamental physiological processes and are now considered important targets for the treatment of various diseases.This paper reviewed the structure,classification,distribution,and signaling pathways of bitter taste receptors,their relationship with different diseases,and the role of bitter taste receptors agonists,aiming to provide a basis for scientific research on bitter taste receptors.
基金项目
国家自然科学基金项目(82060710)
国家自然科学基金项目(82360781)
江西省教育厅科学技术研究项目(GJJ2200951)
江西省创新专项资金项目(YC2023-S758)
江西省2023大学生创新创业训练计划项目(S202310412108)
国家科技期刊平台
NSTL
万方数据