Secondary metabolites of endophytic fungus Talaromyces malicola hosted in Armadillidium vulgare
The secondary metabolites of the endophytic fungus Talaromyces malicola hosted in the arthropod Armadillidium vulgare were separated by silica gel column chromatography,gel column chromatography,and semi-preparative high-performance liquid chromatography.Eleven compounds(1-11)were obtained from the ethyl acetate fraction of the fermentation broth of T.malicola,and their structures were identified by NMR,HR-ESI-MS,UV,IR,and ECD.The 11 compounds were talarosesquiterpene A(1),(3β,5α,6α,15α,22E)-5,6-epoxyergosta-8(14),22-diene-3,7,15-triol(2),vermistatin(3),hydroxyvermistatin(4),bercheminol A(5),penicillide(6),lunatinin(7),penipurdin A(8),emodin(9),BE-25327(10),and(-)-regiolone(11).Compound 1 was a new diaporol-type sesquiterpene.Compounds 2,4-5,and 7-11 were isolated from Talaromyces for the first time.
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