首页|中药糖肽的提取分离、结构鉴定及药理作用研究现状与展望

中药糖肽的提取分离、结构鉴定及药理作用研究现状与展望

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中药糖肽作为一类具有重要生物活性的天然产物,近年来备受关注.该类物质具有抗肿瘤、免疫调节、神经保护、抗炎等多种药理作用.提取和分离直接影响糖肽的得率和纯度,而结构鉴定对于深入理解糖肽的特性和作用机制至关重要.该文对中药糖肽在提取分离、结构鉴定和药理作用研究方面的现状进行了综述,并展望了未来的研究方向.尽管中药糖肽研究取得了一定进展,但依然面临着提取效率低、分离周期长、结构难鉴定、作用机制难阐释等挑战.为应对这些问题,未来的研究可以在不断优化糖肽提取方法的同时,开发新的分离技术并发展高效的结构鉴定方法.同时,深入研究中药糖肽的药理作用机制,将有助于为其在药物开发和临床应用中发挥更大作用提供科学依据.
Extraction,isolation,structural characterization and pharmacological effects of glycopeptides from traditional Chinese medicine:current status and prospects
Glycopeptides of traditional Chinese medicine(GTCM),as a type of natural products with important biological activi-ties,have received increasing attention in recent years.These substances have a variety of pharmacological effects,including anti-tumor,immunomodulatory,neuroprotective,and anti-inflammatory effects.The extraction and separation processes directly affect the yield and purity of GTCM,and structural characterization is essential for probing into the properties and pharmacological mechanisms of glycopeptides.This article reviews the research progress and prospects the research directions in the extraction,separation,structural identification,and pharmacological effects of GTCM.Despite the progress in the research on GTCM,challenges such as low extraction efficiency,long separation cycles,difficult structural characterization,and complex mechanisms still exist.To address these issues,ef-forts should be made to optimize the extraction methods,explore new separation technologies,and develop efficient structural characte-rization methods.Additionally,the future work should decipher the pharmacological mechanisms of GTCM,which will provide a scien-tific basis for the drug development and clinical applications of GTCM.

glycopeptides of traditional Chinese medicineextractionseparation and purificationstructural characterizationpharmacological effect

高叶、陈晓艺、郭盛、宿树兰、段金廒、肖平

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南京中医药大学江苏省中药资源产业化过程协同创新中心/中药资源产业化与方剂创新药物国家地方联合工程研究中心/国家中医药管理局中药资源循环利用重点研究室,江苏南京 210023

中药糖肽 提取 分离纯化 结构鉴定 药理作用

江苏省高校自然科学基金重大项目江苏省中医药科技发展计划项目宁夏重点研发计划重点项目中央本级重大增减支项目国家中医药管理局高水平中医药重点学科建设项目国家中医药管理局中医药创新团队及人才支持计划项目国家级大学生创新创业训练计划项目

24KJA360007MS20210042020BFH020132060302ZYYZDXK-2023083ZYYCXTD-D-202005202410315039Z

2024

10.19540/j.cnki.cjcmm.20240716.301

中国中药杂志
中国药学会

中国中药杂志

CSTPCD北大核心
影响因子：1.718
ISSN：1001-5302
年,卷(期)：2024.49(17)
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