Chemical constituents of Viburnum utile and their inhibitory activities against α-glucosidase
The chemical constituents in the ethanol extract of Viburnum utile were isolated by column chromatography with D101 macroporous resin,silica gel,and Sephadex LH-20.Their structures were identified by spectroscopic techniques such as NMR and MS.All the compounds were evaluated for the inhibitory activities against α-glucosidase.Sixteen compounds were obtained and identi-fied as viburnumide A(1),vitamin E(2),α-amyrin(3),α-tocoquinone(4),narjatamanin B(5),ethyl caffeate(6),naringenin(7),apigenin(8),ethyl β-D-ribo-hex-3-ulopyranoside(9),trans-p-hydroxycinnamic acid(10),amentoflavone(11),apigenin-7-O-β-D-glucoside(12),luteolin-7-O-β-D-glucoside(13),henryoside(14),ursolic acid(15),and 2α-hydroxy-oleanolic acid(16).Among them,compound 1 was a new compound,and compounds 2-16 were isolated from V.utile for the first time.The inhibitory ac-tivity(IC50 of 4.0 μmol·L1)of compound 11 against α-glucosidase was comparable to that of the positive control acarbose(IC50 of 2.3 μmol·L-1).
Viburnum utilechemical constituentsviburnumide Ainhibitory activity against α-glucosidase
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