摘要
随着骨科疾病机制研究的不断深入,传统单靶点疗法的弊端日益暴露,寻求多靶点药物已成为目前骨科相关疾病的主流研究方向.青蒿素是从中药青蒿中提取出的倍半萜内酯类化合物,在青蒿素的基础上研究人员逐渐合成了以双氢青蒿素、青蒿琥酯、蒿甲醚、蒿乙醚为代表的多种青蒿素衍生物.近年来药理学研究发现青蒿素及其衍生物能够通过调节成骨-破骨耦联、调节免疫反应、抑制血管生成、保护软骨、抑制肿瘤生长治疗骨质疏松、骨关节炎、类风湿性关节炎、骨肉瘤等骨科相关疾病.该文将对青蒿素及其衍生物的代谢特点和治疗骨科疾病的作用机制进行综述,以期为青蒿素类药物和骨科疾病的现代研究带来启发.
Abstract
As research into the mechanisms of orthopedic diseases continues to deepen,the shortcomings of traditional single-target the-rapies are becoming increasingly apparent.Consequently,the search for multi-target drugs has become the mainstream research direction for orthopedics-related diseases.Artemisinin,a sesquiterpene lactone compound extracted from Artemisia annua,has led to the gradual synthesis of various derivatives such as dihydroartemisinin,artesunate,artemether,and arteether.Recent pharmacological studies have found that artemisinin and its derivatives can treat osteoporosis,osteoarthritis,rheumatoid arthritis,osteosarcoma,and other orthopedic diseases by regulating osteoblast-osteoclast coupling,modulating immune response,inhibiting angiogenesis,protecting cartilage,and in-hibiting tumor growth.This paper reviewed the metabolic characteristics and mechanisms of action of artemisinin and its derivatives in the treatment of orthopedic diseases,aiming to inspire modern research on artemisinin-based drugs and orthopedic diseases.
基金项目
国家重点研发计划项目(2022YFC3601904)
天津市自然科学基金重点项目(22JCZDJC00340)
天津市卫生健康科技项目(TJWJ2022QN053)
NETL
NSTL
万方数据