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牛黄及其代用品的化学成分及质量控制研究进展

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牛黄是清热解毒、息风止痉的传统中药，常用于心脑血管疾病的治疗。然而，由于其药用资源匮乏及代用品使用范围的局限性，牛黄及其代用品的质量控制备受关注。该文以代用品采用沿革为基础，以化学成分为切入点，从性状-显微-理化鉴别分析到以胆汁酸、胆红素为指标性成分的光谱-色谱-质谱的量化分析，发展至以药效-生物导向关联模式的中药质量标志物(Q-marker)研究，对牛黄及其代用品的质量控制方法进行综述，以期为其质量标准研究提供科学的参考依据。最后，就其全息化学成分解析和核心功效物质在确定的问题进行展望，拟为牛黄及其代用品的合理开发提供参考。
Progress on chemical constituents and quality control of Bovis Calculus and its substitutes
Bovis Calculus,a traditional medicine with the role of clearing away heat and detoxification,extinguishing wind to arrest convulsions,is often used for brain-cerebrovascular diseases.However,the quality control of Bovis Calculus and its substitutes has at-tracted much attention due to the scarcity of resources and limitations of use.Based on the evolution of the use of substitutes and the chemical composition as the entry point,this article reviews the quality control methods from the following three aspects.It covers various analysis methods from characteristic-microscopy-physical and chemical identification analysis to the quantitative analysis of bile acid and bilirubin using spectroscopy,chromatography,and mass spectrometry.Furthermore,it develops to the research of the quality marker(Q-marker)of traditional Chinese medicine(TCM)based on a correlation model of pharmacodynamics and biological direction.The aim is to provide a scientific basis for the quality standards of Bovis Calculus and its substitutes.Finally,the holographic chemical composition analysis and identification of the core effective substances in Bovis Calculus and its substitutes are anticipated to provide valuable insights for guiding strategic development.

Bovis Calculus and its substituteschemical constituentsquality marker(Q-marker)quality control

左池靖、刘艳、汪杰、余卫东、梁万徽、单晓晓、韩岚、彭代银、彭灿

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安徽中医药大学新安医学与中医药现代化研究所,安徽合肥 230012

安徽中医药大学药学院,安徽合肥 230012

安徽中医药大学 安徽省现代中药产业共性技术研究中心,安徽合肥 230012

安徽中医药大学安徽省乡村振兴协同技术服务中心,安徽合肥 230012

省部共建安徽道地中药材品质提升协同创新中心,安徽合肥 230012

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牛黄及代用品 化学成分 质量标志物 质量控制

大健康研究院新安医学与中医药现代化研究所专项安徽省高校杰出青年科研项目安徽省科技重大专项安徽省高校协同创新项目安徽省高校协同创新项目安徽省高校协同创新项目

2023CXMMTCM0062023AH020035202103a07020001GXXT-2022-075GXXT-2022-084GXXT-2020-025

2024

10.19540/j.cnki.cjcmm.20240514.201

中国中药杂志
中国药学会

中国中药杂志

CSTPCD北大核心
影响因子：1.718
ISSN：1001-5302
年,卷(期)：2024.49(18)