健胃消食颗粒作为江中健胃消食片的主要物料，其离散元模型的构建方法与仿真参数的设定尚不清楚，仿真模型精度对颗粒间的动力学响应特性有较大影响，需通过参数标定提高仿真参数的准确性。该文以健胃消食颗粒休止角为响应值，采用响应面法优化标定离散元参数;物理试验测定健胃消食颗粒物性参数，基于Hertz-Mindlin with Johnson-Kendall-Roberts(JKR)V2模型和虚拟仿真方法在EDEM软件中构建休止角测定模型;图像分析与数值拟合方法测定休止角，应用Plackett-Burman试验对离散元仿真中初始参数进行显著性筛选，对其中显著性参数进行最陡爬坡试验，确定最优参数区间;基于Box-Behnken试验建立显著性参数与休止角的二阶回归方程，以物理试验休止角37。64°为目标值，对回归方程进行优化求解。显著性筛选试验得出健胃消食颗粒的颗粒-颗粒静摩擦系数、颗粒-颗粒滚动摩擦力、颗粒-钢板滚动摩擦力对仿真休止角影响显著;最优参数组合:0。330、0。222、0。229。最优参数组合的仿真试验结果表明仿真休止角与物理试验休止角无显著性差异，两者相对误差为0。05％，进一步验证了健胃消食颗粒离散元标定参数的可靠性。
Determination of physical properties and calibration of discrete element simulation parameters for Jianwei Xiaoshi Granules
The construction method and simulation parameter settings for the discrete element model of Jianwei Xiaoshi Granules,as the primary material of Jianwei Xiaoshi Tablets,are not yet clear.The accuracy of the simulation model significantly influences the dynamic response characteristics between granules.Therefore,it is necessary to calibrate the parameters to improve the accuracy of the simulation parameters.Using the repose angle of Jianwei Xiaoshi Granules as the response value,the response surface methodology was employed to optimize and calibrate the discrete element parameters.Physical experiments were conducted to determine the physical properties of Jianwei Xiaoshi Granules.Based on the Hertz-Mindlin with Johnson-Kendall-Roberts (JKR) V2 model and virtual simulation methods,a repose angle determination model was constructed in EDEM software.The repose angle was measured using image analysis and numerical fitting methods.The Plackett-Burman experiment was used to screen the initial parameters for significance in the discrete element simulation.The significant parameters were then subjected to a steepest ascent experiment to determine the optimal parameter range.Furthermore,based on the Box-Behnken experiment,a second-order regression equation between significant parameters and repose angle was established,with the repose angle of 37.64° in the physical experiment as the target value.The regression equation was optimized and solved.The significance screening experiment revealed that the granule-granule static friction coefficient,granule-granule rolling friction,and granule-steel plate rolling friction of Jianwei Xiaoshi Granules significantly influenced the simulated repose angle.The optimal parameter combination was found to be 0.330,0.222,and 0.229.The simulation results with this optimal parameter combination showed that there was no significant difference between the simulated repose angle and the repose angle obtained in the physical experiment,with a relative error of 0.05％,which further validated the reliability of the calibrated discrete element parameters for Jianwei Xiaoshi Granules.
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