基于中药制剂新技术的类风湿性关节炎穴位给药治疗研究进展
Research progress in acupoint administration of new dosage forms of traditional Chinese medicine preparations for rheumatoid arthritis
王狄鑫 1高远 2吴代敏 1吴英倩 1徐剑 2张永萍2
作者信息
- 1. 贵州中医药大学药学院,贵州贵阳 550025
- 2. 贵州中医药大学药学院,贵州贵阳 550025;国家苗药工程技术研究中心,贵州贵阳 550025;贵州中药炮制与制剂工程技术研究中心,贵州贵阳 550025
- 折叠
摘要
传统的穴位给药治疗类风湿性关节炎(rheumatoid arthritis,RA),多以散剂、膏剂、糊剂为给药剂型,但以上剂型存在明显弊端,如透皮吸收量少、皮肤刺激强、易脱离等缺点,创新一种高渗透、低毒、低刺激、给药方便的中药穴位疗法具有重要意义.随着中药现代制剂新技术的发展,将微乳、微粒、水凝胶、脂质体等现代剂型与穴位给药相结合,衍生的治疗方法有穴位贴敷给药、穴位注射给药、微针、纳米多孔针灸针等.中药制剂新技术与穴位给药相结合,起到药物高渗透、高滞留、形成药物"穴位贮库"优势,药物蓄积于穴位持续放大穴位效应的作用,以达到药物治疗与穴位治疗1+1>2的叠加效果.因此该文基于中药制剂新技术与穴位给药相结合治疗RA的相关研究、制剂改良作综述,为中药穴位治疗与现代制剂新技术的结合提供发展新思路.
Abstract
The conventional acupoint therapy for rheumatoid arthritis often uses traditional Chinese medicine preparations in the dosage forms of powder,ointment,and paste.However,these dosage forms have obvious drawbacks,such as low transdermal absorption,strong skin irritation,and easy detachment.Creating a traditional Chinese medicine acupoint therapy characterized by high penetration,low toxicity,low irritation,and convenient administration is of great significance.With the development of new technology for modern traditional Chinese medicine preparations,modern dosage forms such as microemulsion,microparticle,hydrogel,and liposome are combined with acupoint administration,and the derived therapeutic methods include acupoint application,acupoint injection,microneedle,and nanoporous acupuncture needle.The combination of new dosage forms of traditional Chinese medicine preparations and acupoint administration has the advantages of high drug permeability,high retention,and the formation of drug acupoint storage.The accumulation of drugs in acupoints continuously amplifies the acupoint effect,achieving a synergistic effect of drug treatment and acupoint treatment (1+1>2).This article reviews the relevant research and improvement of new dosage forms of traditional Chinese medicine preparations combined with acupoint administration for the treatment of RA,providing new development ideas for the combination of traditional Chinese medicine acupoint therapy and modern new formulation technologies.
关键词
穴位治疗/类风湿性关节炎/纳米载体促渗/中药挥发油促渗/中药制剂/新技术Key words
acupoint therapy/rheumatoid arthritis/promoting permeation of nanocarriers/promoting penetration of traditional Chinese medicine volatile oil/traditional Chinese medicine preparations/new technology引用本文复制引用
出版年
2024
NETL
NSTL
万方数据