摘要
藤黄酸为来源于藤黄中的一种笼状呫吨酮类化合物,被证明是藤黄发挥药理作用的重要物质基础,近年来凭借其广泛且显著的药理活性持续受到关注.现代药理学研究表明,藤黄酸具有抗炎抗氧化、抗肿瘤、改善视网膜病变、脏器保护、抗微生物感染、骨保护与缓解神经病理疼痛等多种治疗活性.然而,目前尚缺乏对藤黄酸药理作用及机制研究的系统总结与整合,而该部分内容对于促进其临床转化具有重要的意义.此外,目前的研究发现藤黄酸在使用过程中具有潜在的安全性风险如器官毒性、发育毒性以及溶血性等.因此,该文对藤黄酸的药理学作用和机制以及毒理学相关信息进行系统梳理和总结,旨在为促进藤黄酸的临床转化提供参考和数据支撑.
Abstract
Gambogic acid,a caged xanthone compound derived from Garcinia,has been proven to be an important substance basis for the pharmacological effects of the plant.In recent years,it has received continuous attention due to its broad and significant pharmacological activities.Modern pharmacological investigations have demonstrated that gambogic acid endows various therapeutic effects such as anti-inflammatory,antioxidant,and anti-tumor activities,as well as benefits in retinopathy,organ protection,anti-microbial infection,bone protection,and neuropathic pain relief.Nevertheless,there is currently a lack of systematic summary and integration of the pharmacological effects and mechanisms of gambogic acid,which is critical for advancing the clinical application of this natural product.In addition,current research has raised concerns about potential safety risks associated with gambogic acid,such as organ toxicity,developmental toxicity,and hemolysis.Given this,this paper systematically reviewed and summarized the pharmacological effects,mechanisms,and toxicological profiles of gambogic acid,aiming to provide reference and data support for its clinical translation.
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