首页|桑黄真菌学、化学成分、生物活性及其发酵工艺调控研究进展

桑黄真菌学、化学成分、生物活性及其发酵工艺调控研究进展

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民族药桑黄为桑黄孔菌属真菌的干燥子实体,在中国及日本、韩国等具有悠久的药用历史.桑黄富含多糖类、黄酮类、三萜类、多酚类等活性物质,可发挥抗癌、抗氧化、降血糖、降血脂、保肝、抗炎、抑菌、缓解痛风等多种活性,在医药、食品领域具有广阔的应用和开发前景,但野生桑黄资源稀缺、人工栽培的桑黄基原多样、有关桑黄的地方标准不统一、桑黄菌丝体的开发相对滞后等问题的存在,在一定程度上限制了桑黄资源的持续开发.基于此,该文针对桑黄资源现状、化学成分、生物活性、桑黄发酵工艺及其过程调控等相关研究进行综述,以期为桑黄资源的可持续利用提供参考.
Mycology,chemical components,bioactivities,and fermentation process regulation of Sanghuang:a review
Sanghuang,a famous ethnomedicine widely used in China,Japan,Korea and other countries for a long history,is produced from the dried fruiting bodies of the medical fungi belonging to Sanghuangporus.With abundant bioactive natural chemicals including polysaccharides,flavonoids,triterpenoids,and polyphenols,Sanghuang exhibits anticancer,antioxidant,blood glucose-and lipid-lowering,liver protecting,anti-inflammatory,antimicrobial,and gout symptom-relieving effects,thus demonstrating broad application and development prospects in the pharmaceutical and food fields.However,the sustainable development of Sanghuang resources is limited by the scarce stock of wild resources,the diverse original fungi of cultivated Sanghuang,the inconsistency of local standards of Sanghuang materials or products,and the lagging application of Sanghuangporus mycelia.In view of the shortages mentioned above,this article reviews the research progress in the current situation of Sanghuang resources,the chemical composition,bioactivities,and fermentation process regulation of Sanghuangporus strains,and the related biosynthesis regulating strategies for enhancing the production of bioactive metabolites.This review is expected to provide comprehensive information for the sustainable development and utilization of Sanghuang resources.

Sanghuangmycologybioactive componentscomprehensive developmentfermentation processbiosynthesis of bioactive metabolites

彭思源、贺建、江国政、丁婵、蒋彭成、龚婕、厉晓、崔培梧

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湖南中医药大学药学院菌物药研究室,湖南长沙 410208

国家中医药管理局中药药性与药效三级科研实验室,湖南长沙 410208

陕西事事顺景农业发展有限责任公司,陕西商洛 726308

西藏跑山堂药材开发有限公司,西藏拉萨 850006

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桑黄 真菌学 活性成分 综合开发 发酵工艺 活性代谢产物生物合成

2024

中国中药杂志
中国药学会

中国中药杂志

CSTPCD北大核心
影响因子:1.718
ISSN:1001-5302
年,卷(期):2024.49(24)
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