A Review of the Effects of the FGF23-Klotho Endocrine Axis on Blood Vessels of Brain and Stroke
Fibroblast growth factor 23(FGF23)-Klotho endocrine axis is involved in phosphate metabolism,and is closely related to the pathogenesis of stroke.FGF23 and Klotho levels are associated with the incidence and prognosis of stroke.The FGF23-Klotho endocrine axis is involved in the regulation of vascular inflammation and may be involved in the pathological process of stroke risk factors such as hypertension,insulin resistance,lipid metabolism and obesity.In this paper,the influence and mechanism of FGF23-Klotho endocrine axis on stroke were reviewed in order to bring new ideas for clinical treatment and prevention of stroke.
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