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临床预测模型开发与验证的样本量估算

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临床预测模型在医学领域的应用受到越来越多的关注和重视.合理且充足的样本量对预测模型研究的可行性和质量保障具有重要意义.基于此,本文总结了临床预测模型开发和验证中的样本量估算策略,提出了在样本量估算时需重点关注的问题,同时探讨了样本量不足的问题,以期能够帮助研究者合理地估算预测模型所需的样本量,从而提高临床预测模型研究的质量.
Sample Size Estimation for the Development and Validation of Clinical Prediction Models
The application of clinical prediction models in the medical field is receiving increasing attention.Reasonable and sufficient sample size is of great importance to the feasibility and quality assurance of prediction model research.Based on this,this paper summarized the strategies for sample size estimation in the development and validation of clinical prediction models,outlined the key issues that should be paid attention to in sample size estimation,and also discussed the problems related to insufficient sample size,to help researchers estimate the sample size reasonably and improve the quality of clinical prediction model research.

Clinical prediction modelSample sizeModel developmentModel validation

姜英玉、谷鸿秋

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北京 100070 首都医科大学附属北京天坛医院国家神经系统疾病临床医学研究中心

临床预测模型 样本量 模型开发 模型验证

国家自然科学基金北京市医院管理中心"青苗"人才计划北京市医院管理中心"培育"人才计划

72004146QML20210501PX2021024

2024

中国卒中杂志
中国科学技术信息研究所(ISTIC) 科学技术文献出版社

中国卒中杂志

CSTPCD北大核心
影响因子:1.069
ISSN:1673-5765
年,卷(期):2024.19(5)